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Exercise Induced Asthma and Airway Reactivity in Athletes

This study has been completed.
Sponsor:
Information provided by:
Skåne University Hospital
ClinicalTrials.gov Identifier:
NCT00798564
First received: November 25, 2008
Last updated: August 2, 2011
Last verified: September 2008
History of Changes

November 25, 2008
August 2, 2011
March 2008
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Complete list of historical versions of study NCT00798564 on ClinicalTrials.gov Archive Site
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Exercise Induced Asthma and Airway Reactivity in Athletes
Explorative Study "Exercise Induced Asthma and Airway Reactivity in Athletes"

The overall aim is to explore pathophysiological factors related to airway hyperresponsiveness to direct and indirect provocation stimuli in athletes with different sport activities, with special focus on epithelial reaction linked to CC16 and to eicosanoid related inflammatory response. The investigators also wish to compare indirect testing done as hyper osmotic challenge with Mannitol compared to a defined sport specific exercise challenge.

By non-invasive tools the investigators wish to characterize type of airway reaction to various provocative stimuli in athletes doing two different sort activities, Tennis or swimming. As controls are being used sedentary age-matched controls from the same region, exposed to the same school environment. Thus we wish to:

  • explore the prevalence of positive mannitol reactivity among swimmers and tennis player and how this relates to symptoms, disease history and to a sport specific exercise provocation test.
  • compare the results from sport specific testing with a standardized eucapnic hyperventilation test (EHV)
  • compare the overall reactivity to mannitol or EHV among swimmers and tennis players compared to aged matched controls.
  • explore the role by CC16 in airway reactivity to different provocative stimuli and to see whether there is a difference between different sport activities, different test protocols and between athletes and controls.
  • explore evidence of eicosanoid related inflammatory reaction in athletes and controls in relation to different provocative stimuli

The study population consists of 100 elite swimmers, 100 elite tennis players and 100 non-elite, eged matched controls. In the latter group, 30 are aged matched non-atopic non-asthmatic controls.
Observational
Time Perspective: Cross-Sectional
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Probability Sample

100 elite swimmers 100 elite tennis players 100 aged matched non-atletic subjects, 30 aged-matcked healthy non-atopic controls
Respiratory Function Tests
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
300
December 2009
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Inclusion Criteria:

  • Subjects aged 16-19 from Skåne.
  • All should approve attendance in the study by signing an informed consent. Igf they are aged under 18, parents should also sign.
  • Three groups are included
  • Elite aspiring swimmers with an average training intensity of at least hours per week the last year.

Exclusion Criteria:
Both
16 Years to 25 Years
Yes
Contact information is only displayed when the study is recruiting subjects
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NCT00798564
34797
No
Professor Leif Bjermer, Lung and Alllergy research unit, Heart & Lung division, Lund University Hospital
Skåne University Hospital
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Principal Investigator: Leif H Bjermer, MD, PhD Lund University
Skåne University Hospital
September 2008

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP