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Acute Kidney Injury After Cardiac Surgery Based on KDIGO Criteria

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Mauricio de Nassau Machado, Hospital de Base
ClinicalTrials.gov Identifier:
NCT00777465
First received: October 21, 2008
Last updated: May 19, 2014
Last verified: May 2014

October 21, 2008
May 19, 2014
January 2003
June 2013   (final data collection date for primary outcome measure)
Acute Kidney Injury after cardiac surgery as a independent predictor of 30-day mortality [ Time Frame: 30 days ] [ Designated as safety issue: No ]
To test the hypothesis that the acute kidney injury based on KDIGO criteria after cardiac surgery is a independent predictor of 30-day mortality
To test the hypothesis that patients with acute kidney injury after cardiac surgery have higher 30-day mortality. [ Time Frame: 30 days ] [ Designated as safety issue: No ]
Complete list of historical versions of study NCT00777465 on ClinicalTrials.gov Archive Site
Not Provided
  • To identify risk factors associated with acute kidney injury after cardiac surgery. [ Time Frame: 30 days ] [ Designated as safety issue: No ]
  • To compare clinical outcomes in patients with and without acute kidney injury after cardiac surgery [ Time Frame: 30 days ] [ Designated as safety issue: No ]
Not Provided
Not Provided
 
Acute Kidney Injury After Cardiac Surgery Based on KDIGO Criteria
Prognostic Value of Acute Kidney Injury After Cardiac Surgery According to Kidney Disease: Improving Global Outcomes Definition and Staging (KDIGO) Criteria

The aim of this study was to apply the acute kidney injury criteria based on KDIGO classification in a population of patients undergoing cardiac surgery [coronary artery bypass grafting (CABG) or cardiac valve surgery (CVS)] and evaluate its impact as a predictor of 30-day mortality.

This was a single center study. We evaluated retrospectively patients from the Cardiac Surgery Intensive Care Unit in Hospital de Base, São José do Rio Preto Medical School, São Paulo, Brazil. Demographics, type of surgery, laboratory data and preoperative, perioperative, and postoperative information were retrieved from a prospectively collected database of 2878 patients older than 18 years undergoing isolated CABG (1786) or CVS (1092), from January 2003 to June 2013. After applying the exclusion criteria (51 patients with incomplete data and 23 patients with end-stage kidney disease) we analyzed 2804 patients in total, 1738 (62%) underwent CABG and 1066 (38%) underwent CVS.

Observational
Observational Model: Cohort
Time Perspective: Prospective
Not Provided
Not Provided
Probability Sample

Patients selected consecutively after cardiac surgery (CABG or CVS) in a setting of postoperative intensive care unit.

Acute Kidney Injury
Not Provided
  • KDIGO 0
    Patients with no acute kidney injury after cardiac surgery
  • KDIGO 1
    Patients with acute kidney injury KDIGO stage 1 after cardiac surgery (Increase in SCr by ≥ 0.3 mg/dL (≥ 26.5 lmol/L) or 1.5 to 1.9 times baseline)
  • KDIGO 2
    Patients with acute kidney injury KDIGO stage 2 after cardiac surgery (2.0 to 2.9 times baseline SCr)
  • KDIGO 3
    Patients with acute kidney injury KDIGO stage 3 after cardiac surgery (3.0 times baseline or more; or increase in SCr to ≥ 4.0 mg/dL; or initiation of renal replacement therapy)
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
2804
June 2013
June 2013   (final data collection date for primary outcome measure)

Inclusion Criteria:

patients undergoing isolated coronary artery bypass grafting or cardiac valve surgery.

Exclusion Criteria:

patients with incomplete data and patients with end-stage kidney disease.

Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
Brazil
 
NCT00777465
CAAE-3436.0.000.140-08
No
Mauricio de Nassau Machado, Hospital de Base
Hospital de Base
Not Provided
Study Director: Lilia N Maia, PhD São José do Rio Preto Medical School
Hospital de Base
May 2014

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP