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Ventricular Remodeling In Patients With Aortic Stenosis Assessed Echocardiography

This study has been withdrawn prior to enrollment.
(Unable to identify and recruit suitable study subjects)
Sponsor:
Collaborator:
Tufts Medical Center
Information provided by (Responsible Party):
Lahey Clinic
ClinicalTrials.gov Identifier:
NCT00774657
First received: October 16, 2008
Last updated: February 16, 2012
Last verified: February 2012
History of Changes

October 16, 2008
February 16, 2012
September 2008
February 2012   (final data collection date for primary outcome measure)
Evaluate 2-dimensional and 3-dimensional echocardiography for LV patterns of remodeling and hypertrophy [ Time Frame: 1 hour ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT00774657 on ClinicalTrials.gov Archive Site
Assess doppler diastolic filling indices for patterns of LV remodeling [ Time Frame: 1 hour ] [ Designated as safety issue: No ]
Same as current
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Ventricular Remodeling In Patients With Aortic Stenosis Assessed Echocardiography
Patterns Of Left Ventricular Remodeling In Patients With Aortic Stenosis Assessed By Two-Dimensional And Three-Dimensional Echocardiography

This preliminary study will compare the effectiveness of two-dimensional and three-dimensional echocardiographic measurements of wall thickness and left ventricular mass in patients with Aortic Stenosis

This study will evaluate left ventricular patterns of remodeling and hypertrophy in patients with aortic stenosis, and compare two-dimensional echocardiography measurements (wall thickness) with three-dimensional echocardiography data(left ventricular mass). Along with a second objective to assess Doppler diastolic filling indices associated with the various patterns of left ventricular remodeling.

Previous studies(see reference list) were primarily derived from two-dimensional echo data set(based on wall thickness). Various patterns of left ventricular remodeling have been described in response to increased pressure overload.

Three-dimensional echocardiography is a relatively new technique that is being increasingly used in the Echocardiography Lab in selected patients. This technique holds promise of being more accurate for volume-related measurements than the standard 2-dimensional echocardiography techniques.
Observational
Observational Model: Cohort
Time Perspective: Prospective
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Non-Probability Sample

Lahey Clinic patients who have been referred to the echocardiography lab for clinical indications, found to have a aortic stenosis
Aortic Stenosis
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Withdrawn
0
February 2012
February 2012   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Subjects more than 18 yrs of age through 90 yrs of age
  • Both male and female
  • Patients with moderate or severe isolated Aortic Stenosis
  • Patients who have been referred for both two-dimensional and three- dimensional echocardiographies.

Exclusion Criteria:

  • Poor acoustic windows
  • h/o CAD and wall motion abnormality
Both
18 Years to 90 Years
No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00774657
2008-090
No
Lahey Clinic
Lahey Clinic
Tufts Medical Center
Principal Investigator: Sherif B. Labib, M.D. Lahey Clinic, Inc.
Lahey Clinic
February 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP