Insulin Sensitivity and Metabolism Before and After Treatment in Patients With Hypothyroidism

This study has been terminated.
(no longer interested in doing the study)
Sponsor:
Collaborator:
MR Research Center, Skejby Sygehus, Brendstrupgaardsvej 100, 8200 Aarhus N
Information provided by:
University of Aarhus
ClinicalTrials.gov Identifier:
NCT00770016
First received: October 8, 2008
Last updated: October 25, 2010
Last verified: October 2010

October 8, 2008
October 25, 2010
January 2010
January 2010   (final data collection date for primary outcome measure)
  • intracellular lipid content in liver and muscle [ Time Frame: before and after 3 months treatment with growth hormone ] [ Designated as safety issue: No ]
  • intraabdominal lipid content [ Time Frame: before and after treatment ] [ Designated as safety issue: No ]
  • insulin sensitivity [ Time Frame: before and after treatment ] [ Designated as safety issue: No ]
  • substrate metabolism [ Time Frame: before and after treatment ] [ Designated as safety issue: No ]
  • intracellular signaling in the basal state and during insulin stimulation [ Time Frame: before and after treatment ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT00770016 on ClinicalTrials.gov Archive Site
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Not Provided
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Insulin Sensitivity and Metabolism Before and After Treatment in Patients With Hypothyroidism
Insulin Sensitivity and Metabolism Before and After Treatment in Patients With Hypothyroidism

The aim of this study is to further characterize the treatment related changes in insulin sensitivity, substrate metabolism and intra hepatic- and intramyocellular lipid content in patients with hypothyroidism

Not Provided
Interventional
Not Provided
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
Hypothyroidism
Drug: Levothyroxin
Dosage regulation will follow the local recommendations of treatment
Other Name: Eltroxin (Levothyroxin, GlaxoSmithKline Pharma)
Experimental: 1
the aim of the present study is to characterize the treatment related changes in insulin sensitivity, substrate metabolism and intrahepatic - intramyocellular lipids in 12 adult patients, recently diagnosed with hypothyroidism
Intervention: Drug: Levothyroxin
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Terminated
0
January 2011
January 2010   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • written informed consent
  • must be of legal age and competent
  • Age > 18 years
  • presently diagnosed with hypothyroidism

Exclusion Criteria:

  • alcohol consumption >21 units per week
  • Malignant disease
  • pregnancy
  • magnetic implants or material in the body
  • BMI > 30
  • Heart disease (NYHA >2)
  • Uncontrolled hypertension
  • Manifest diabetes mellitus
  • Changes in medication, with any influence on glucose metabolism, 2 months prior to and until the end of the trial.
Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
Denmark
 
NCT00770016
LM_HYPO_2008
Yes
Jens Otto Lunde Jorgensen, Medical Department M, Aarhus University Hospital, Aarhus Sygehus, Norrebrogade 44, 8000 Aarhus C
University of Aarhus
MR Research Center, Skejby Sygehus, Brendstrupgaardsvej 100, 8200 Aarhus N
Not Provided
University of Aarhus
October 2010

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP