Evaluation of Wound Biofilm in Acute and Chronic Wounds

This study has been withdrawn prior to enrollment.
(withdrawn as MSU approval obained)
Sponsor:
Information provided by (Responsible Party):
Randall Wolcott, Southwest Regional Wound Care Center
ClinicalTrials.gov Identifier:
NCT00764348
First received: September 30, 2008
Last updated: September 6, 2011
Last verified: September 2011

September 30, 2008
September 6, 2011
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It is important for all wound care providers to firmly grasp the wound biofilm concept, its importance in delayed wound healing, and how it differs from a planktonic bacterial concept. [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT00764348 on ClinicalTrials.gov Archive Site
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Evaluation of Wound Biofilm in Acute and Chronic Wounds
Evaluation of Wound Biofilm in Acute and Chronic Wounds

Patients who present to a wound care center for management of their wounds will be evaluated clinically to establish if their wounds are chronic or acute. These patients will undergo standard of care management of their wounds. If debridement is indicated for the patient, the patient will be asked to participate in a study. Once the standard of care debridement is complete, the material debrided from the wound, instead of being discarded into a biohazard bag, will be prepared for shipment. The samples will then be shipped to the Center for Biofilm Engineering where microscopic evaluation will be conducted on the material. Conclusion will be made from that analysis.

A planktonic concept of the bacteria present on the surface of a chronic wound is no longer viable. Microscopic studies show that biofilm is present on chronic wounds yet does not seem to be prominent on the surface of acute wounds. Biofilm is able to neutralize our host defenses and commandeer host systems, and possesses an impressive array of defenses and virulence factors. Clinically we see a significant difference in the healing behavior between chronic and acute wounds. Also, suppression of biofilm using multiple simultaneous strategies including debridement, anti-biofilm agents, specific biocides, antibiotics and advanced technologies improves wound healing. This suggests biofilm plays an important role in delayed wound healing.

Observational
Time Perspective: Prospective
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Retention:   Samples With DNA
Description:

traumatic, diabetic foot ulcer, decubitus ulcer, venous leg ulcer

Non-Probability Sample

Acute and Chronic Wounds

Wounds
Other: no treatment
no treatment
Intervention: Other: no treatment
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Withdrawn
0
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Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
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NCT00764348
56-RW-002
No
Randall Wolcott, Southwest Regional Wound Care Center
Southwest Regional Wound Care Center
Not Provided
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Southwest Regional Wound Care Center
September 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP