Surveillance of Influenza Virus Among Children With Febrile Respiratory Complaints Attending the Pediatric Clinic of the First Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong, Mainland China

This study is currently recruiting participants. (see Contacts and Locations)
Verified July 2014 by St. Jude Children's Research Hospital
Sponsor:
Collaborators:
The University of Hong Kong
Information provided by (Responsible Party):
St. Jude Children's Research Hospital
ClinicalTrials.gov Identifier:
NCT00760500
First received: September 25, 2008
Last updated: July 9, 2014
Last verified: July 2014

September 25, 2008
July 9, 2014
January 2004
December 2014   (final data collection date for primary outcome measure)
To identify Influenza A or B and the subtype of Influenza A of the isolates from children with febrile respiratory complaints who attend the pediatric clinic of the First Affiliated Hospital, Shantou University Medical College. [ Time Frame: This is an epidemiologic study, there is no time frame. ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT00760500 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
Surveillance of Influenza Virus Among Children With Febrile Respiratory Complaints Attending the Pediatric Clinic of the First Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong, Mainland China
Surveillance of Influenza Virus Among Children With Febrile Respiratory Complaints Attending the Pediatric Clinic of the First Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong, Mainland China

The surveillance of influenza virus among children with febrile reparatory complaints attending the pediatric clinic in Shantou is an epidemiologic study to identify the type (influenza A or B) and the subtype of Influenza A of the isolates from children with febrile respiratory complaints who attend the pediatric clinic of the first Affiliated Hospital, Shantou University Medical College, Shantou Guangdong, China. Also this study investigates the genetic composition of all segments of isolated strains using standard molecular techniques and to make available the new strains of influenza viruses isolated from such children for the formulation of influenza vaccines. Clinical manifestation of the respiratory illness is recorded and single nasopharyngeal swab is obtained from eligible children. Viral culture is performed on the nasopharyngeal secretions. If influenza is isolated, this is characterized if it belongs to influenza A or B. If the virus is characterized as influenza A, further antigenic studies is done to determine subtype of influenza. Viral isolates is further studied to determine the genetic composition of the virus. Information obtained from the viral isolates is shared with the WHO and the CDC.

OBJECTIVES

Primary objective:

  • To identify the type (Influenza A or B) and the subtype of Influenza A of the isolates from children with febrile respiratory complaints who attend the pediatric clinic of the First Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong, China.

Secondary objectives

  • To investigate the genetic composition of all segments of isolated strains using standard molecular techniques.
  • To make available the new strains of influenza viruses isolated from such children for the formulation of influenza vaccines.
Observational
Observational Model: Ecologic or Community
Time Perspective: Prospective
Not Provided
Retention:   Samples Without DNA
Description:

Nasopharyngeal specimen taken by swab

Non-Probability Sample

Children between the ages of 0 months and 18 years (inclusive) who have been seen at the pediatric clinic of the First Affiliated Hospital within 7 days of the onset of signs and symptoms of febrile respiratory illness suspected to be of viral origin (temperature > 37.7ºC or reliable history of fever before being examined, and respiratory symptoms and signs such as cough, sore throat, and coryza).

  • Influenza Type A
  • Influenza Type B
Other: Nasopharyngeal Swab
Nasopharyngeal Swab
1
Intervention: Other: Nasopharyngeal Swab
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
16000
December 2014
December 2014   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Age: 0 day to 18 years.
  • Patient was seen at the pediatric clinic of the First Affiliated Hospital within 7 days of the onset of signs and symptoms of febrile respiratory illness suspected to be of viral origin (temperature > 37.7ºC or reliable history of fever before being examined, and respiratory symptoms and signs such as cough, sore throat, and coryza).
  • Parents agree to a nasopharyngeal specimen being taken by swab from their child.

Exclusion Criteria:

  • Patient is too ill to tolerate a nasopharyngeal specimen swab.
Both
up to 18 Years
No
Contact: Miguela Caniza, MD 1-866-278-5833 info@stjude.org
China
 
NCT00760500
SIVFRC, N01AI70005
No
St. Jude Children's Research Hospital
St. Jude Children's Research Hospital
  • The University of Hong Kong
  • National Institute of Allergy and Infectious Diseases (NIAID)
Principal Investigator: Miguela Caniza, MD St. Jude Children's Research Hospital
St. Jude Children's Research Hospital
July 2014

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP