The objective of this study is to investigate the efficacy and side effects of a fractional CO2 laser for treatment of acne scar in Asians.

• The objective of this study is to investigate the efficacy and side effects of a fractional CO2 laser for treatment of acne scar in Asians.

• Study hypothesis

  1. Reduction in acne scars based on blinded evaluation of before photos and the one and three month follow-up photos after four full face Ellipse Juvia with low density treatments with a fluency of 90-105 mJ/MTZ is statistically significant (5%).
  2. The direct clinical blinded evaluated reduction in acne scars based on before photos and the patient in life, by the one and three month follow-up is statistically significant (5%)
  3. Reduction in fine lines based on blinded evaluation of before photos and the one and three month follow-up photos after four full face Ellipse Juvia with low density treatments with a fluency of 90-105 mJ/MTZ is statistically significant (5%).
  4. The direct clinical blinded evaluated reduction in fine lines based on before photos and the patient in life, by the one and three month follow-up is statistically significant (5%).
  5. Reduction in pigmented disorders based on blinded evaluation of before photos and the one and three month follow-up photos after four full face Ellipse Juvia with low density treatments with a fluency of 90-105 mJ/MTZ is statistically significant (5%).
  6. The direct clinical blinded evaluated reduction in pigmented disorders based on before photos and the patient in life, by the one and three month follow-up is statistically significant (5%).
  7. Improvements in skin texture and pore size based on blinded evaluation of before photos and the one and three month follow-up photos after four full face Ellipse Juvia with low density treatments with a fluency of 90-105 mJ/MTZ is statistically significant (5%).
  8. The direct clinical blinded evaluated reduction in skin texture and pore size based on before photos and the patient in life, by the one and three month follow-up is statistically significant (5%).

• Fitzpatrick RE. Laser resurfacing today and the "cookbook" approach: a recipe for disaster? A comment. J Cosmet Dermatol. 2005 Dec;4(4):298-9. No abstract available.
• Fitzpatrick RE, Goldman MP, Satur NM, Tope WD. Pulsed carbon dioxide laser resurfacing of photo-aged facial skin. Arch Dermatol. 1996 Apr;132(4):395-402.
• Alster TS, Lupton JR. Erbium:YAG cutaneous laser resurfacing. Dermatol Clin. 2001 Jul;19(3):453-66. Review.
• Manstein D, Herron GS, Sink RK, Tanner H, Anderson RR. Fractional photothermolysis: a new concept for cutaneous remodeling using microscopic patterns of thermal injury. Lasers Surg Med. 2004;34(5):426-38.

Inclusion Criteria:

• Numbers of volunteers: 10 healthy men and women
• Aged at least 30 year old
• Skin type: 1 - 4
• Degree of suntan: None - light
• Skin condition: visible acne scars

Exclusion Criteria:

• Fitzpatrick skin types 5-6.
• Patients with lesions with any clinical suspicion of being pre-cancerous or skin malignancies of any kind.
• Patients with skin diseases associated with Koebner phenomena.
• Patients who have used Botox or filler injection to the periorbital or perioral regions 12 months prior or during the study.
• Patients who have used topical retinoids, AHA under prescription or Vitamin C, 3 months prior to or during the study.
• Patients who are pregnant or who wish to become pregnant and lactating women.
• Patients who have been exposed to sun within 2 week from date of treatment.
• Patients prone to hypertrophic scars or keloids
• Patients who have previously undergone laser resurfacing may not be suitable for yet another procedure.
• Patients undergoing oral retinoid therapy for acne in the past 6 months.
• Patients who suffer from any serious medical condition, including diabetes, bleeding diathesis, delayed wound healing or prednisolone intake.
• Patients with wound infections (herpes, other) on the day of treatment.
• Patients with moderate and severe inflammatory acne, Immunosuppressed patients, History of vitiligo.
• Patients with unrealistic concerns/expectations and inability to do the appropriate post-operative care.