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Acute Effects of Smoking on Airway Dendritic Cells

This study has been completed.
Sponsor:
Collaborator:
German Research Foundation
Information provided by:
University of Rostock
ClinicalTrials.gov Identifier:
NCT00740896
First received: August 22, 2008
Last updated: April 7, 2009
Last verified: April 2009

August 22, 2008
April 7, 2009
June 2008
November 2008   (final data collection date for primary outcome measure)
Total number of dendritic cells in bronchoalveolar lavage fluid [ Time Frame: June - September 2008 ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT00740896 on ClinicalTrials.gov Archive Site
Surface molecule expression on dendritic cells in bronchoalveolar lavage fluid [ Time Frame: June - September 2008 ] [ Designated as safety issue: No ]
Same as current
Not Provided
Not Provided
 
Acute Effects of Smoking on Airway Dendritic Cells
Acute Effects of Smoking on Airway Dendritic Cells

Airway dendritic cells control pulmonary immune responses to inhaled particles. It is the aim of the present study to investigate the acute effects of smoking on the number and surface molecule expression of human airway dendritic cells.

Not Provided
Interventional
Not Provided
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Basic Science
Tobacco Use Disorder
  • Behavioral: Smoking
    Active Comparator: Participants smoke 8 cigarettes in 4 hours.
  • Behavioral: Smoking
    Sham Comparator: Participants are not allowed to smoke for 4 hours.
  • Active Comparator: 1
    Participants smoke 8 cigarettes in 4 hours.
    Intervention: Behavioral: Smoking
  • Sham Comparator: 2
    Participants are not allowed to smoke for 4 hours.
    Intervention: Behavioral: Smoking
Bratke K, Klug M, Bier A, Julius P, Kuepper M, Virchow JC, Lommatzsch M. Function-associated surface molecules on airway dendritic cells in cigarette smokers. Am J Respir Cell Mol Biol. 2008 Jun;38(6):655-60. Epub 2008 Jan 18.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
16
December 2008
November 2008   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Active smoking (at least 10 cigarettes per day)
  • Age > 18 years

Exclusion Criteria:

  • Any chronic diseases
  • Any regular medication
  • Any signs or symptoms of an acute infection
Both
18 Years and older
Yes
Contact information is only displayed when the study is recruiting subjects
Germany
 
NCT00740896
LO-2222
No
PD Dr. med. Marek Lommatzsch, University of Rostock
University of Rostock
German Research Foundation
Study Chair: Johann C. Virchow, Professor, MD, FRCP, FCCP University of Rostock
University of Rostock
April 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP