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Use of Electroconvulsive Therapy (ECT) in Chronic, Severe, Treatment Resistant Posttraumatic Stress Disorder

This study has been completed.
Sponsor:
Collaborator:
Government Psychiatric Diseases Hospital, Srinagar
Information provided by:
Government Medical College Srinagar
ClinicalTrials.gov Identifier:
NCT00739856
First received: August 20, 2008
Last updated: August 21, 2008
Last verified: August 2008

August 20, 2008
August 21, 2008
January 2005
December 2005   (final data collection date for primary outcome measure)
Clinician-Administered Posttraumatic Stress Disorder Scale (CAPS) SCORE [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT00739856 on ClinicalTrials.gov Archive Site
Montgomery-Asberg Depression Rating Scale score [ Time Frame: baseline, 48 hrs post 3rd, 6th ECT ] [ Designated as safety issue: No ]
Same as current
Not Provided
Not Provided
 
Use of Electroconvulsive Therapy (ECT) in Chronic, Severe, Treatment Resistant Posttraumatic Stress Disorder
Efficacy of ECT in Chronic, Severe, Antidepressant- And CBT-Refractory Posttraumatic Stress Disorder: An Open, Prospective Study

Post Traumatic Stress Disorder is a chronic debilitating illness and few treatment options have demonstrated effectiveness. The study will look at the use of electroconvulsive therapy for the treatment of Post Traumatic Stress disorder in patients who have not responded to multiple antidepressants or cognitive behavioral therapy.

Not Provided
Interventional
Not Provided
Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Posttraumatic Stress Disorder
Procedure: Electroconvulsive Therapy
ECT was administered using the MECTA-SR1 apparatus. The current amplitude was 800 mA, pulse width was 1.5 ms, and pulse frequency was 50 Hz. Stimulus duration was increased as required to elicit an adequate seizure, defined as at least 25 s with EEG monitoring. The ECT course was fixed, and comprised 6 treatments administered with bitemporal electrode placement at a twice-weekly frequency
Not Provided
Margoob MA, Ali Z, Andrade C. Efficacy of ECT in chronic, severe, antidepressant- and CBT-refractory PTSD: an open, prospective study. Brain Stimul. 2010 Jan;3(1):28-35. Epub 2009 May 27.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
20
Not Provided
December 2005   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Diagnosis of PTSD
  • Treatment resistance to 4 different antidepressants from 3 different classes
  • Treatment resistance to CBT
  • Severe PTSD

Exclusion Criteria:

  • Significant substance abuse
  • Pregnancy
  • History of Traumatic Brain Injury
  • Unstable comorbid medical illness
  • Organic brain syndrome
Both
18 Years to 65 Years
No
Contact information is only displayed when the study is recruiting subjects
India
 
NCT00739856
GMCPTSD_ECT2005
No
Not Provided
Government Medical College Srinagar
Government Psychiatric Diseases Hospital, Srinagar
Principal Investigator: Mushtaq Margoob, MD Government Medical College Srinagar
Government Medical College Srinagar
August 2008

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP