Optical Coherence Tomography of the Airway for Lung Cancer or Lung Disease

This study has been withdrawn prior to enrollment.
(Low interest)
Sponsor:
Collaborator:
Information provided by (Responsible Party):
Case Comprehensive Cancer Center
ClinicalTrials.gov Identifier:
NCT00733252
First received: August 12, 2008
Last updated: March 21, 2012
Last verified: March 2012

August 12, 2008
March 21, 2012
April 2008
January 2011   (final data collection date for primary outcome measure)
Correlation of optical coherence tomography images of the airway with airway histology [ Time Frame: This study will involve discarded tissue from 10 subjects with pathology specimens over one year. ] [ Designated as safety issue: No ]
Correlation of optical coherence tomography images of the airway with airway histology [ Designated as safety issue: No ]
Complete list of historical versions of study NCT00733252 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
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Not Provided
 
Optical Coherence Tomography of the Airway for Lung Cancer or Lung Disease
Optical Coherence Tomography of Human Airways

RATIONALE: Diagnostic procedures, such as optical coherence tomography, may help find and diagnose lung cancer or precancerous cells.

PURPOSE: This phase I trial is studying how well optical coherence tomography of the airway works in detecting abnormal cells in patients undergoing surgery for lung cancer or lung disease.

OBJECTIVES:

  • Correlate optical coherence tomography images of the airway with airway histology.
  • Develop an imaging technique to detect premalignant airway epithelial changes (carcinoma in situ, dysplasia) to study the transformation process as well as intervene and prevent the development of lung cancer.

OUTLINE: Bronchoscopic imaging and optical coherence tomography are performed on lung tissue samples collected during surgery. All imaged areas are marked. The marked areas are then excised and fixed in formalin for histopathologic analysis.

Observational
Observational Model: Case-Only
Time Perspective: Retrospective
Not Provided
Retention:   Samples Without DNA
Description:

Fresh Bronchi from 10 subjects undergoing pneumonectomy or lobectomy for malignant and benign processes will be obtained from the UHCMC Pathology Department as discarded tissue from fresh specimens

Probability Sample

primary care clinic

  • Lung Cancer
  • Malignant Mesothelioma
  • Metastatic Cancer
  • Nonmalignant Neoplasm
  • Precancerous Condition
  • Procedure: bronchoscopic and lung imaging studies
    Bronchoscopic imaging and optical coherence tomography are performed on lung tissue samples collected during surgery.
  • Procedure: diagnostic bronchoscopy
    Bronchoscopic imaging and optical coherence tomography are performed on lung tissue samples collected during surgery.
  • Procedure: histopathologic examination
    All imaged areas are marked. The marked areas are then excised and fixed in formalin for histopathologic analysis.
  • Procedure: optical coherence tomography
    Bronchoscopic imaging and optical coherence tomography are performed on lung tissue samples collected during surgery.
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Withdrawn
0
February 2011
January 2011   (final data collection date for primary outcome measure)

DISEASE CHARACTERISTICS:

  • Undergoing pneumonectomy or lobectomy for malignant or benign lung processes

PATIENT CHARACTERISTICS:

  • Not specified

PRIOR CONCURRENT THERAPY:

  • See Disease Characteristics
Both
Not Provided
No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00733252
CASE1508, P30CA043703, CASE1508, CASE-1508-CC483
Yes
Case Comprehensive Cancer Center
Case Comprehensive Cancer Center
National Cancer Institute (NCI)
Principal Investigator: Rana Hejal, MD Case Medical Center, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center
Case Comprehensive Cancer Center
March 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP