Sperm Capacitation Assay as a Tool to Predict Sperm Potential to Fertilize in IVF Treatment

The recruitment status of this study is unknown because the information has not been verified recently.
Verified July 2008 by Assaf-Harofeh Medical Center.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Assaf-Harofeh Medical Center
ClinicalTrials.gov Identifier:
NCT00731159
First received: August 7, 2008
Last updated: NA
Last verified: July 2008
History: No changes posted

August 7, 2008
August 7, 2008
July 2008
January 2009   (final data collection date for primary outcome measure)
Fertilization rate of human oocytes in thr "routine" IVF Laboratory work [ Time Frame: One year ] [ Designated as safety issue: No ]
Same as current
No Changes Posted
Not Provided
Not Provided
Not Provided
Not Provided
 
Sperm Capacitation Assay as a Tool to Predict Sperm Potential to Fertilize in IVF Treatment
Sperm Capacitation Assay as a Tool to Predict Sperm Potential to Fertilize in IVF Treatment

Our aim is to evaluate the potential of a new laboratory method that measure sperm capacitation to predict fertilization of oocytes in patients that undergo IVF treatments

Capacitation is a physiologic process in which the sperm acquire the potential to fertilize oocytes. Capacitation can be measured, but the available technics are expensive, inaccurate and complex. A new method to evaluate sperm capacitation was developed in Bar Ilan University, Israel. We intend to measure the capacitation of semen that is used for fertilizing human oocytes in patients treated at the IVF unit at Assaf Harofeh Medical Center.By this, to evaluate the potential of the new method to predict human oocyte fertilization.If the method will be found valuable, it will enable to develop new drugs/methods that may improve sperm capacitation and by this to improve oocyte fertilization leading to more embryos, pregnancies and deliveries.

Observational
Time Perspective: Prospective
Not Provided
Not Provided
Non-Probability Sample

Patients requiring IVF within the "routine" work of an IVF Unit

Sperm Capacitation
  • Biological: sperm capacitation
    sperm capacitation measured at Bar Ilan University
  • Other: biologic
    sperm synthesis of G-actine to F-actine
    Other Name: sperm capacitation
  • Other: sperm capacitation
    sperm synthesis of G-actine to F-actine
    Other Name: sperm synthesis of G-actine to F-actine
A

Sperm capacitation:

Sperm capacitation is measured in a sample of the same ejaculated sperm unit given for fertilizing human oocytes in an IVF treatment cycle

Interventions:
  • Biological: sperm capacitation
  • Other: biologic
  • Other: sperm capacitation
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
50
July 2009
January 2009   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Patients requiring IVF within the "routine" work of an IVF Unit
  • normo-responding woman
  • non ICSI cycles

Exclusion Criteria:

  • Patients undergoing ICSI only cycle
  • Low responders-less than 8 oocytes
  • Male patients with low semen volume
Both
18 Years to 40 Years
Yes
Contact: arieh raziel, prof 97289779005 araziel@asaf.health.gov.il
Contact: raphael ron-el, prof 97289779005 rronel@asaf.health.gov.il
Israel
 
NCT00731159
54/08
No
Prof A Raziel, Assaf Harofeh MC
Assaf-Harofeh Medical Center
Not Provided
Not Provided
Assaf-Harofeh Medical Center
July 2008

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP