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Acute Stroke Program of Interventions Addressing Racial and Ethnic Disparities (ASPIRE)

This study has been completed.
Sponsor:
Collaborators:
Medstar Research Institute
Howard University
Washington Hospital Center
George Washington University
University of Michigan
University of Wisconsin, Madison
Johns Hopkins University
University of Alabama at Birmingham
MedStar Good Samaritan Hospital
Union Memorial Hospital
Information provided by (Responsible Party):
Chelsea Kidwell, M.D., Georgetown University
ClinicalTrials.gov Identifier:
NCT00724555
First received: July 28, 2008
Last updated: January 30, 2014
Last verified: January 2014

July 28, 2008
January 30, 2014
February 2008
January 2013   (final data collection date for primary outcome measure)
The proportion of people with ischemic stroke appropriately treated with IV tPA. [ Time Frame: 4 years ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT00724555 on ClinicalTrials.gov Archive Site
Qualitative data collected from the community will identify baseline levels of knowledge, attitudes, and perceived and encountered barriers to acute stroke treatment. [ Time Frame: 1 year ] [ Designated as safety issue: No ]
Same as current
Not Provided
Not Provided
 
Acute Stroke Program of Interventions Addressing Racial and Ethnic Disparities
Acute Stroke Program of Interventions Addressing Racial and Ethnic Disparities

The purpose of this study is to increase treatment of acute stroke with tissue plasminogen activator (tPA) across the District of Columbia. This study, however, will not evaluate tPA as an intervention.

There are a number of well-known barriers to receiving tissue plasminogen activator (tPA) including transit time to hospital, paramedic and provider training, tPA standing orders, and provider guidelines. Among underserved populations, limited stroke knowledge, socioculturally determined attitudes, and beliefs and myths held by community members may serve as additional barriers that hinder these populations from receiving tPA and acute stroke care. Targeted multilevel interventions designed to overcome specific barriers may significantly increase the number of individuals with stroke who are appropriately treated with intravenous tPA (IV tPA) in underserved communities. Identification of the specific components of healthcare interventions that are the most effective is critical to improve delivery of acute stroke therapy.

The goal of this study is to learn more about public knowledge, attitudes, beliefs and perceptions regarding stroke and stroke treatment in order to identify sociocultural and environmental barriers to receiving tPA and acute stroke care in an underserved community. This study will also determine if implementation of a multilevel intervention program can significantly increase the number of people with ischemic stroke who are appropriately treated with IV tPA in a predominantly underserved community.

In the study, researchers will evaluate the different levels of the intervention to determine which efforts are most effective.

Observational
Observational Model: Ecologic or Community
Time Perspective: Prospective
Not Provided
Not Provided
Non-Probability Sample

Adult residents of the District of Columbia

Stroke
Not Provided
1
Adults living in DC neighborhoods with high proportions of underserved adults. The age of the cohort members will reflect the age of DC residents who suffer most from stroke.
Boden-Albala B, Edwards DF, St Clair S, Wing JJ, Fernandez S, Gibbons MC, Hsia AW, Morgenstern LB, Kidwell CS. Methodology for a community-based stroke preparedness intervention: the Acute Stroke Program of Interventions Addressing Racial and Ethnic Disparities Study. Stroke. 2014 Jul;45(7):2047-52. doi: 10.1161/STROKEAHA.113.003502. Epub 2014 May 15.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
2005
January 2013
January 2013   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • diagnosis of acute ischemic stroke
  • over the age of 18

Exclusion Criteria:

-

Both
18 Years and older
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00724555
U54NS057405_ASPIRE, 2007-439
No
Chelsea Kidwell, M.D., Georgetown University
Georgetown University
  • Medstar Research Institute
  • Howard University
  • Washington Hospital Center
  • George Washington University
  • University of Michigan
  • University of Wisconsin, Madison
  • Johns Hopkins University
  • University of Alabama at Birmingham
  • MedStar Good Samaritan Hospital
  • Union Memorial Hospital
Principal Investigator: Chelsea Kidwell, MD Georgetown University
Georgetown University
January 2014

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP