Assess Vitamin D Levels in Those With & Without Thyroid Cancer

This study has been completed.
Sponsor:
Information provided by:
University of Nebraska
ClinicalTrials.gov Identifier:
NCT00719615
First received: July 17, 2008
Last updated: March 15, 2010
Last verified: March 2010

July 17, 2008
March 15, 2010
March 2008
March 2009   (final data collection date for primary outcome measure)
Number of Persons That Are Vitamin D Deficient in the Thyroid Nodule, Thyroid Cancer in Remission, and the Active Thyroid Cancer Groups. [ Time Frame: Within 12 months of enrollment in thyroid cancer collaborative registry (TCCR) database ] [ Designated as safety issue: No ]
We evaluated serum calcium,creatinine,albumin,and 25-hydroxyvitaminD(25-OH-D)in 42 thyroid nodule, 45 thyroid cancer in remission, & 24 active thyroid cancer patients. We also determined the number and percent of participants in each group that had vitamin D deficiency, defined as 25-OH-D < 30 ng/ml.
Assess percentage of persons with vitamin D levels in the deficient range (25-OH-D <30ng/ml) with active thyroid cancer compared to those in remission and controls. [ Time Frame: Within 12 months of enrollment in thyroid cancer collaborative registry database ] [ Designated as safety issue: No ]
Complete list of historical versions of study NCT00719615 on ClinicalTrials.gov Archive Site
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Assess Vitamin D Levels in Those With & Without Thyroid Cancer
The Relationship Between Vitamin D and Thyroid Cancer

The purpose of this study is to evaluate Vitamin D levels in thyroid cancer patients with active disease compared with thyroid cancer patients in remission and patients with thyroid nodules.

Thyroid cancer is the most common endocrine related malignancy, increasing in incidence in recent years. There are relatively few, well known factors, both genetic and environmental, which predispose to the development of thyroid cancer. Vitamin D deficiency has been associated with other cancers, but the association between vitamin D and thyroid cancer is unknown. We plan to do a case control, pilot study to evaluate the relationship between vitamin D levels and thyroid nodules, thyroid cancer in remission, and active thyroid cancer.

Observational
Observational Model: Case Control
Time Perspective: Prospective
Not Provided
Retention:   Samples With DNA
Description:

Whole blood.

Non-Probability Sample

The Thyroid Tumor and Cancer Collaborative Registry (TCCR) is a thyroid cancer and thyroid nodule database at the University of Nebraska Medical Center. The database serves as a registry and biospecimen bank for those who wish to participate in multidisciplinary research. The database will be accessed to query for individuals with a diagnosis of thyroid cancer, both active disease and in remission, as well as a diagnosis of thyroid nodules. Those meeting eligibility requirements will then have their registry information and stored biospecimens accessed for testing and review.

Thyroid Cancer
Not Provided
  • Thyroid Cancer in Remission Group
    Thyroid Cancer-Remission Group & use of Vitamin D
  • Thyroid Cancer with Active Disease Group
    Thyroid Cancer-Active Group & use of Vitamin D
  • Thyroid nodule group (no cancer) & Vit D
    Thyroid nodule group without cancer and use of Vitamin D

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
111
June 2009
March 2009   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Cases: History of Papillary, Follicular, Follicular Variant of Papillary, or Hurthle cell thyroid cancer (both active disease and in remission).
  • Controls: Individuals with a thyroid nodule, matched to cases for age, BMI, season of vitamin D measurement.
  • Participating in University of Nebraska Medical Center Thyroid Tumor and Cancer Collaborative Registry database.

Exclusion Criteria:

  • Pregnant or breast feeding women
  • Medullary thyroid cancer
  • Anaplastic thyroid cancer
Both
19 Years and older
No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00719615
136-08-EP
No
Whitney Goldner, MD, University of Nebraska Medical Center
University of Nebraska
Not Provided
Principal Investigator: Nathan W Laney, MD University of Nebraska Medical Center, Department of Internal Medicine, Section of DEM
University of Nebraska
March 2010

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP