Determinants of Pterygium Occurrence and Recurrence in a Rural African Population

• corneal scarring [ Time Frame: 6 months of follow up ] [ Designated as safety issue: Yes ]
• tenon's granuloma [ Time Frame: 6 months of follow up ] [ Designated as safety issue: Yes ]
• graft retraction [ Time Frame: one month of follow up ] [ Designated as safety issue: Yes ]
• Graft haematoma [ Time Frame: one week of follow up ] [ Designated as safety issue: Yes ]
• Graft hyperaemia [ Time Frame: 3 months of follow up ] [ Designated as safety issue: Yes ]

The aim of the study is to find out why pterygium occurs and recurs in a rural African population. Participants will be interviewed on personal and lifestyle information, family history of pterygium, environmental exposure and history of previous eye inflammation. They will undergo eye examination and photography. Those with pterygium will be operated on to remove pterygium and followed up to detect any recurrence and complications of surgery. The excised pterygium will be examined pathologically and genetically; participant's blood will also be examined genetically. Data will be analyzed for statistically significant differences in findings between pterygium and pterygium free participants.

The study hypothesis is that multiple factors are responsible for the occurrence and recurrence of pterygium in a rural african population.

• No Intervention: 1
  Pterygium free participants
• Experimental: 2
  Pterygium participants
  Intervention: Procedure: Pterygium excision followed by grafting

Inclusion Criteria:

1. Pterygium at least 1.5mm in extent
2. Both male and female
3. Age range 21-65 years
4. Consenting to participate in study
5. Unilateral and bilateral pterygium
6. All grades of pterygium

Exclusion Criteria:

1. Previous cataract, corneoscleral and glaucoma surgery or corneoscleral trauma and corneolimbal scars
2. Pseudopterygium or signs of malignancy on pterygium
3. Recurrent pterygium
4. Sufferers of collagen vascular disease, scleritis or diabetes -