Endoscopic Saphenous Vein Harvest for Coronary Artery Bypass Grafting

This study has been completed.
Sponsor:
Information provided by:
Far Eastern Memorial Hospital
ClinicalTrials.gov Identifier:
NCT00712192
First received: July 7, 2008
Last updated: July 8, 2008
Last verified: July 2008

July 7, 2008
July 8, 2008
January 2007
December 2007   (final data collection date for primary outcome measure)
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Complete list of historical versions of study NCT00712192 on ClinicalTrials.gov Archive Site
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Endoscopic Saphenous Vein Harvest for Coronary Artery Bypass Grafting
The Impact on Endothelial Function and Integrity by Endoscopic Saphenous Vein Harvest for Coronary Artery Bypass Grafting

Although the long saphenous vein remains the most commonly used conduit in coronary revascularization, traditional open vein harvest may lead to significantly impaired wound healing and post-operative pain. To this end, endoscopic saphenous vein harvesting techniques have been shown to reduce post-operative morbidity. Studies have shown that endothelial integrity and luminal nitric oxide synthase (NOS) are better preserved with novel "no-touch" techniques; however, the effect and the associated mechanism of endoscopic vein harvest on endothelial integrity and function remain unknown. Therefore, in the present proposal, we will collect the saphenous vein segements immediately after harvesting, reperfusion, and grafting, and then use enzyme-linked immunosorbant assay (ELISA), immunohistochemical staining (IHC), and real-time polymerase chain reaction (RT-PCR) to detect the expression and distribution of endothelial NOS (eNOS), endothelin-1 (ET-1), vascular cell adhesion molecule-1 (VCAM-1), intracellular adhesion molecule-1 (ICAM-1), and platelet endothelial cell adhesion molecule-1(PECAM-1) at protein and RNA levels in the endothelium of saphenous veins. The major aim of this study is to elucidate the effect and mechanism of endoscopic saphenous vein harvesting on endothelial properties as compare to conventional open vein harvest technique.

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Interventional
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Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
Coronary Artery Disease
Procedure: coronary artery bypass grafting
patient with coroary artery diseases underwent coronary artery bypass grafting surgery
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
34
December 2007
December 2007   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • patient with coronary artery disease underwent coronary artery bypass grafting in our hospital

Exclusion Criteria:

  • no
Both
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No
Contact information is only displayed when the study is recruiting subjects
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NCT00712192
95016, FEMH - 95 - C -002
Yes
Shih-Hong Huang, Far Eastern Memorial Hospital
Far Eastern Memorial Hospital
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Far Eastern Memorial Hospital
July 2008

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP