Investigation of the Immuno-regulation and Viral Hepatitis Among Patients With or After Dengue Fever Infection

This study is currently recruiting participants. (see Contacts and Locations)
Verified January 2014 by Kaohsiung Medical University Chung-Ho Memorial Hospital
Sponsor:
Collaborator:
Information provided by (Responsible Party):
Kaohsiung Medical University Chung-Ho Memorial Hospital
ClinicalTrials.gov Identifier:
NCT00688389
First received: May 28, 2008
Last updated: February 9, 2014
Last verified: January 2014

May 28, 2008
February 9, 2014
July 2007
December 2014   (final data collection date for primary outcome measure)
檢查肝臟、腎臟及其他生化功能,並分析宿主免疫調控及血小板變化機致 [ Time Frame: 2007/7/1 ] [ Designated as safety issue: Yes ]
抽血20 c.c 檢查肝臟、腎臟及其他生化功能,並分析宿主免疫調控及血小板變化機致
Not Provided
Complete list of historical versions of study NCT00688389 on ClinicalTrials.gov Archive Site
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Investigation of the Immuno-regulation and Viral Hepatitis Among Patients With or After Dengue Fever Infection
Follow-up the Health Condition , Investigation of the Immuno-regulation , and the Study for Interaction of Viral Hepatitis--- Among Patients With or After Dengue Fever Infection

The study will collect the blood samples from 350 healthy persons and 350 persons infected with dengue fever.

Research has showed that CLEC5A interacts with dengue virion directly, and is responsible for dengue virus (DV)-induced DAP12 phosphorylation. Data suggests that CLEC5A is a potential therapeutic target for dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS). This project will study the genes of CLEC5A, Mannose receptor, DC-SIGN, NALP, decoy receptor 3 (DcR3), Toll-like receptors(TLRs), and (Nod)-like receptors (NLRs) for both DF and DHF groups. In addition, serum level of decoy receptor 3 (DcR3) will be tested. The study will collect the blood samples from 350 healthy persons and 350 persons infected with dengue fever.

Observational
Observational Model: Case Control
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Non-Probability Sample

The samples are obtained from the Kaohsiung Medical University Chung-Ho Memorial Hospital in Kaohsiung, Taiwan.

Dengue Fever
Genetic: CLEC5A
SNP (Single Nucleotide Polymorphism) genetic analysis of CLEC5A receptor (from exon 1 to exon 7)
  • healthy
    Intervention: Genetic: CLEC5A
  • DF
    Intervention: Genetic: CLEC5A
  • DHF
    Intervention: Genetic: CLEC5A
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
700
December 2014
December 2014   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Clinical diagnosis of Dengue fever

Exclusion Criteria:

  • none
Both
Not Provided
Yes
Contact: Jih-Jin Tsai, MD 886-7-312-1101 ext 5677 jijits@cc.kmu.edu.tw
Taiwan
 
NCT00688389
KMUH-IRB-960195_1, CB9615
No
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung Medical University Chung-Ho Memorial Hospital
Centers for Disease Control and Prevention
Not Provided
Kaohsiung Medical University Chung-Ho Memorial Hospital
January 2014

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP