Now Available for Public Comment: Notice of Proposed Rulemaking (NPRM) for FDAAA 801 and NIH Draft Reporting Policy for NIH-Funded Trials

A Study to Investigate the Pharmacology of a Dual Pharmacophore in Healthy Volunteers

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
GlaxoSmithKline
ClinicalTrials.gov Identifier:
NCT00687700
First received: May 28, 2008
Last updated: May 31, 2012
Last verified: February 2011

May 28, 2008
May 31, 2012
March 2008
May 2008   (final data collection date for primary outcome measure)
To assess the bronchodilation of single doses of GSK961081 over 24 hours following ß blockade with the ß antagonist propranolol as measured by sGaw in healthy subjects.
Same as current
Complete list of historical versions of study NCT00687700 on ClinicalTrials.gov Archive Site
  • Assess safety of GSK961081 after single doses of it with&without ß blockade with propranolol as measured by specific indicators
  • Adverse events, clinical laboratory safety tests, FEV1, vital signs, 12-lead ECG parameters, blood glucose and serum potassium.
  • Propranolol and GSK961081blood levels to derive pharmacokinetics
  • Assess systemic pharmacokinetics of GSK961081 and propranolol after single doses of both
Same as current
Not Provided
Not Provided
 
A Study to Investigate the Pharmacology of a Dual Pharmacophore in Healthy Volunteers
A Study to Investigate the Relative Pharmacological Activity of Aninhaled B2-agonist/Anticholinergic Dual Pharmacophore Inhealthy Volunteers

Study will investigate the pharmacodynamics of a dual pharmacophore in which a combination of GSK961081 and Propanolol is used to give a total effect of bronchodilation.

Not Provided
Interventional
Phase 1
Allocation: Randomized
Endpoint Classification: Pharmacodynamics Study
Intervention Model: Crossover Assignment
Masking: Double-Blind
Primary Purpose: Treatment
  • Pulmonary Disease, Chronic Obstructive
  • Healthy Subjects
  • Drug: GSK961081
  • Drug: Propanolol
    Other Names:
    • Propanolol
    • GSK961081
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
23
May 2008
May 2008   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Healthy adult males aged between 18 and 50 years.
  • Body mass index within the range 19-29.9 kg/m2.
  • FEV1 ≥ 80% predicted and a FEV1/ Forced Vital Capacity (FVC) ratio ≥ 0.7
  • Signed and dated written informed consent is obtained from the subject
  • The subject is able to understand and comply with the protocol requirements, instructions and protocol-stated restrictions.
  • The subject has an increase in sGAW of ≥15% over pre-dose baseline within 2 h of administration of 400 µg salbutamol by MDI inhaler at screening or in the 3 months before screening.
  • The subject has an increase in sGAW of ≥25% over pre-dose baseline within 2 h following 80 µg ipratropium bromide at screening or in the 3 months before screening.
  • Subjects who are current non-smokers who have not used any tobacco products in the 6-month period preceding the screening visit and have a pack history of ≥ 10 pack years.

Exclusion Criteria:

  • Any clinically relevant abnormality identified at the screening medical assessment (physical examination/medical history), clinical laboratory tests, or ECG (12-lead or Holter).
  • A history of respiratory disease (i.e. history of asthmatic symptoms).
  • Clinically significant abnormal 12 lead ECG at
  • A subject in whom ipratropium bromide, salbutamol or propranolol are contraindicated.
  • A supine blood pressure that is persistently higher than 140/90 millimetres of mercury (mmHg) at screening.
  • A supine mean heart rate outside the range 45-90 beats per minute (bpm) at screening.
  • The subject has donated a unit of blood within the 56 days or intends to donate within 56 days after completing the study.
  • The subject is currently taking regular (or course of) medication whether prescribed or not (with the exception of contraceptives, including vitamins and herbal remedies such as St John's Wort.
  • The subject has used prescription or non-prescription drugs, including vitamins, herbal and dietary supplements (including St John's Wort) within 7 days (or 14 days if the drug is a potential enzyme inducer) or 5 half-lives (which ever is longer) prior to the first dose of study medication, unless in the opinion of the Investigator and medical monitor the medication will not interfere with the study procedures or compromise subject safety.
  • The subject has participated in a clinical study with a New Chemical Entity (NCE) within the past 3 months.
  • Exposure to more than four new chemical entities within 12 months prior to the first dosing day.
  • The subject is infected with the Hepatitis B, Hepatitis C, or HIV virus.
  • The subject has a positive pre-study urine cotinine/ breath carbon monoxide test, urine drug/urine alcohol screen.
  • A history of regular alcohol consumption exceeding weekly intake of alcohol greater than 28 units for males, or an average daily intake of greater than 4 units.
  • Are unable to use the inhaler correctly.
  • The subject has a history of drug or other allergy, which, in the opinion of the Investigator, contraindicates their participation.
  • The subject has had a lower respiratory tract infection within 4 weeks of study start.
  • Subject is unable to perform the sGAW measurements
Male
18 Years to 50 Years
Yes
Contact information is only displayed when the study is recruiting subjects
United Kingdom
 
NCT00687700
MAB110553
No
GlaxoSmithKline
GlaxoSmithKline
Not Provided
Study Director: GSK Clinical Trials GlaxoSmithKline
GlaxoSmithKline
February 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP