Magnevist (SH L 451A) Intra-Individual Dose Comparison Study in Patients With Brain Metastasis

• Visibility [ Time Frame: MRI image in blinded read ] [ Designated as safety issue: No ]
• Diagnostic confidence [ Time Frame: MRI image in blinded read ] [ Designated as safety issue: No ]

To verify the number of metastatic brain tumors detected in contrast-enhanced MRI, which is the primary variable, increases after an additional dose of Magnevist (SH L 451A) comparing images after an initial dose (0.1 mmol/kg) with those after an additional dose (0.1 mmol/kg, a total dose of 0.2 mmol/kg) intra-individually in patients with metastatic brain tumors. Safety was also to be assessed.

• Drug: Magnevist (SH L 451A)
  Magnevist at a dose of 0.1 mmol/kg
• Drug: Magnevist (SH L 451A)
  Magnevist at a dose of 0.1 mmol/kg and another 0.1 mmol/kg 30minutes later.

• Active Comparator: Arm 1
  Intervention: Drug: Magnevist (SH L 451A)
• Experimental: Arm 2
  Intervention: Drug: Magnevist (SH L 451A)

Inclusion Criteria:

• Patients who are confirmed to have 1-5 metastatic brain tumor by the latest contrast-enhanced cerebral CT or contrast-enhanced cerebral MRI, and the lesion(s) have not been treated by surgery or by stereotactic radiosurgery.

Exclusion Criteria:

• Patients who are scheduled to receive another contrast medium for MRI (except for oral agents) or iodine contrast medium (except for oral agents), or to undergo surgical procedures during the period from the day before administration of Magnevist (SH L 451A) to examination of safety on the following day.
• Patients who underwent or are scheduled to undergo radiotherapy during the period from 14 days before administration of Magnevist (SH L 451A) to examination of safety on the following day.
• Patients who were treated or are scheduled to be treated with anti-cancer agents (except for treatment only by the oral agents of the fixed dose continuously from 28 days or more before administration of Magnevist (SH L 451A)) during the period from 28 days before administration of Magnevist (SH L 451A) to examination of safety on the following day.