Efficacy of Vitamin C Injection on Fatigue in Workers After Work

• Reactive oxygen species [ Time Frame: Before intravenous vitamin C injections, right after completing injections, and one day later ] [ Designated as safety issue: No ]
• Plasma vitamin C level [ Time Frame: Before intravenous vitamin C injections and right after completing injections ] [ Designated as safety issue: No ]

• Reactive oxygen species [ Time Frame: Before intravenous injections, right after completing injections, and one day later ] [ Designated as safety issue: No ]
• Vitamin C blood level [ Time Frame: Before intravenous injections and right after completing injections ] [ Designated as safety issue: No ]

Fatigue is one of the most frequently observed symptoms for company workers, and oxidative stress is regarded as one of its cause. Vitamin C is a well-known antioxidant, and the investigators seek for evidence of the efficacy of high dose vitamin C parenteral supplement on fatigue symptoms of company workers after work.

Previous studies dealing with vitamin C were focusing on terminal cancer patients or those with chronic fatigue syndrome. Since used drug dosage and the ways of administering vitamin C were not identical, the results were not consistent throughout those studies. This study is aimed to evaluate the efficacy of high dose vitamin C with parenteral supplement on relieving fatigue for apparently healthy volunteers.

• Dietary Supplement: Ascorbic acid (Vitamin C)
  Single intravenous injection of vitamin C 10g(20ml) with 100ml of normal saline over 30 minutes
  Other Names:

  • Ascorbic acid
  • Merit C
• Dietary Supplement: Normal saline
  Single intravenous injection of 120ml of normal saline over 30 minutes
  Other Name: normal saline

• Experimental: 1
  Intravenous injections of 10 grams(20ml as a solution) of vitamin C with 100ml of normal saline over 30 minutes.
  Intervention: Dietary Supplement: Ascorbic acid (Vitamin C)
• Placebo Comparator: 2
  Intravenous injections of 120ml of normal saline over 30 minutes.
  Intervention: Dietary Supplement: Normal saline

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Inclusion Criteria:

• Company workers working at least 5 days a week from morning to evening
• Volunteers who provided written informed consent

Exclusion Criteria:

• Acute illness
• Chronic disease such as diabetes, hypertension, liver disease, or renal disease
• Previous history of renal stone or gout
• Pregnant or lactating women
• Hypersensitivity to vitamins or intravenous injections
• History of vitamin supplements orally or parenterally within 2 days