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The Correlation Between Oxidative Stress and Indinated Contrast-Media Nephrotoxicity

This study has been completed.
Sponsor:
Information provided by:
Far Eastern Memorial Hospital
ClinicalTrials.gov Identifier:
NCT00632892
First received: March 3, 2008
Last updated: March 10, 2008
Last verified: February 2008

March 3, 2008
March 10, 2008
December 2007
January 2008   (final data collection date for primary outcome measure)
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Complete list of historical versions of study NCT00632892 on ClinicalTrials.gov Archive Site
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The Correlation Between Oxidative Stress and Indinated Contrast-Media Nephrotoxicity
The Correlation Between Oxidative Stress and Indinated Contrast-Media Nephrotoxicity

Clinically, iodinated contrast-medium (CM) is widely used in angiography and computerized tomography. CM-induced nephropathy (CMIN) is one major complication after application of CM. Therefore, how to prevent CMIN is always one of the hot topics concerned by nephrologists, cardiologists, and radiologists.

The present study is aimed to determine the norepinephrine concentration, oxidative markers, and tubular damage markers in the urine samples of patients undergoing intravenous pyelography (IVP).

The working hypothesis is high-osmolarity contrast media (HOCM) causes more oxidative stress and greater tubular damage than iso-osmolarity contrast media (IOCM).

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Observational
Observational Model: Case-Only
Time Perspective: Prospective
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Retention:   Samples Without DNA
Description:

The urine samples are collected just before and 30 minutes after IVP.The samples are immediately frozen at -80'C until analyzed.

Non-Probability Sample
  1. Adult patients (> 18 years old)
  2. Undergoing IVP with an appropriate medical indication
  3. Signing informed consent
Kidney Diseases
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
80
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January 2008   (final data collection date for primary outcome measure)

Inclusion Criteria:

  1. Adult patients (> 18 years old)
  2. Undergoing IVP with an appropriate medical indication
  3. Signing informed consent

Exclusion Criteria:

1. Without signing informed consent

Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
Taiwan
 
NCT00632892
96013
Yes
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Far Eastern Memorial Hospital
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Far Eastern Memorial Hospital
February 2008

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP