Vitamin A, Its Receptors and Asthma

This study has been withdrawn prior to enrollment.
Sponsor:
Information provided by (Responsible Party):
Selina Gierer, D.O., University of Kansas
ClinicalTrials.gov Identifier:
NCT00628329
First received: February 26, 2008
Last updated: May 3, 2012
Last verified: May 2012

February 26, 2008
May 3, 2012
May 2008
December 2012   (final data collection date for primary outcome measure)
Retinol levels in blood, flow cytometric study of the RXRRAR receptors before and after addition of ATRA, 9-cis-RA and steroid [ Time Frame: 2-4 weeks after blood sample drawn ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT00628329 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
Vitamin A, Its Receptors and Asthma
Vitamin A, Its Receptors and Asthma: Vitamin A Levels in Serum and Expression and Responsiveness of Vitamin A Receptors in Circulating Mononuclear Cells of Asthmatics

We wish to understand the association of Vitamin A serum levels and Vitamin A receptor number and responsiveness in asthmatics. We believe that Vitamin A receptors may be less prevalent in asthmatics and their responsiveness decreased.

We wish to define the association of asthma, vitamin A serum levels and vitamin A receptor number and responsiveness on circulating mononuclear cells. Asthma is a complex, heterogenous and often debilitating and potentially deadly disease. The causes for asthma are many, with susceptibility and resistance to treatment is poorly understood. Ultimately, looking at this disease from another angle such as the role of Vitamin A and/or receptors can help us learn more about the pathophysiology and treatment of asthma.

Observational
Observational Model: Cohort
Time Perspective: Cross-Sectional
Not Provided
Retention:   Samples With DNA
Description:

Serum without DNA, cells with DNA

Non-Probability Sample

Male or female Age 18-64

Asthma
Not Provided
  • 1
  • 2
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Withdrawn
0
December 2012
December 2012   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Patients with previously diagnosed asthma on inhaled corticosteroids, systemic steroids and/or long acting beta agonist (for a period of 6 mo to 5 years)
  • Age 18-64
  • Male or female

Exclusion Criteria:

  • Children under age 18
  • Adults 65 or older
  • Patients with COPD
Both
18 Years to 64 Years
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00628329
11213
No
Selina Gierer, D.O., University of Kansas
University of Kansas
Not Provided
Principal Investigator: Daniel Stechschulte, MD University of Kansas
University of Kansas
May 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP