How Does Your Genetic Make-up (Profile) Influence Your Glaucoma?

This study has been completed.
Sponsor:
Collaborators:
Jefferson Medical College of Thomas Jefferson University
Thomas Jefferson University
Information provided by (Responsible Party):
George L. Spaeth MD, Wills Eye
ClinicalTrials.gov Identifier:
NCT00626847
First received: February 20, 2008
Last updated: December 31, 2012
Last verified: December 2012

February 20, 2008
December 31, 2012
March 2008
August 2009   (final data collection date for primary outcome measure)
The investigators will quantify the spectrum of changes in mitochondrial respiration, relative mitochondrial DNA content, and oxidative stress associated with different types of glaucoma. [ Time Frame: one blood draw ] [ Designated as safety issue: No ]
We will sequence the entire mitochondrial genome to determine mitochondrial DNA nucleotide changes associated with different types of glaucoma in ethnic Americans. [ Time Frame: unknown ] [ Designated as safety issue: No ]
Complete list of historical versions of study NCT00626847 on ClinicalTrials.gov Archive Site
Not Provided
We will quantify the spectrum of changes in mitochondrial respiration, relative mitochondrial DNA content, and oxidative stress associated with different types of glaucoma. [ Time Frame: unknown ] [ Designated as safety issue: No ]
Not Provided
Not Provided
 
How Does Your Genetic Make-up (Profile) Influence Your Glaucoma?
Nuclear Genetic and Mitochondrial Influences in Glaucoma

Glaucoma is a group of diseases in which visual loss occurs because of damage to the optic nerve. Research has shown that certain genes may cause glaucoma in some cases. So far, research has only been able to find the genes responsible for glaucoma in a small percentage of people who have glaucoma. The purpose of this project is to study the genes in patients with and without glaucoma to find additional genes that may be responsible for causing glaucoma.

Four tubes of blood will be taken from 100 people. Of those, half will have primary open angle glaucoma (POAG) and the other half will be controls (normals), half will be caucasians and the other half will be african americans, half male and half female. All groups will have a routine ophthalmic eye exam, color vision, snellen vision, and visual field done.

Observational
Observational Model: Cohort
Time Perspective: Prospective
Not Provided
Retention:   Samples With DNA
Description:

whole blood

Non-Probability Sample

glaucoma clinic

Primary Open Angle Glaucoma
Not Provided
  • 1
    Primary Open Angle Glaucoma (POAG)
  • 2
    Controls (Normals, patients without glaucoma)
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
97
August 2009
August 2009   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • 40 yrs
  • Caucasian or African American
  • Male or female with POAG, PACG, PXFG,
  • Normal

Exclusion Criteria:

  • Other ophthamic co-morbidities
  • Other ethnic groups
  • Unable to understand and give informed consent
Both
40 Years and older
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00626847
IRB#07-826
No
George L. Spaeth MD, Wills Eye
Wills Eye
  • Jefferson Medical College of Thomas Jefferson University
  • Thomas Jefferson University
Principal Investigator: George L Spaeth, MD Wills Eye Institute
Wills Eye
December 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP