Family Study of Lymphoproliferative Disorders

This study is currently recruiting participants.
Verified September 2013 by Mayo Clinic
Information provided by (Responsible Party):
Susan Slager, Mayo Clinic Identifier:
First received: February 20, 2008
Last updated: September 26, 2013
Last verified: September 2013

February 20, 2008
September 26, 2013
April 2004
July 2016   (final data collection date for primary outcome measure)
Risk of blood or lymphoma [ Time Frame: Ongoing ] [ Designated as safety issue: No ]
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Complete list of historical versions of study NCT00626496 on Archive Site
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Family Study of Lymphoproliferative Disorders
Genetic Epidemiology of Lymphoproliferative Disorders

Blood and lymph node cancers can begin in either the lymphatic tissues (as in the case of lymphoma) or in the bone marrow (as with leukemia and myeloma), and they all are involved with the uncontrolled growth of white blood cells. There are many subtypes of these cancers, e.g., chronic lymphocytic leukemia and non-Hodgkin lymphoma. Since there is evidence that these cancers cluster in families, this study aims to understand how genetics and environmental exposures contribute to the development of these cancers.

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Observational Model: Family-Based
Time Perspective: Prospective
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Retention:   Samples With DNA

We will collect blood samples from patients and their relatives for DNA and cytogenetic studies. A one time blood draw of 50 cc will be done.

Non-Probability Sample

Adults over the age of 18 who have a family history of a blood or lymph node disorder.

  • Lymphoma, Non-Hodgkin
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Lymphoma, B-Cell
  • Monoclonal B-Cell Lymphocytosis
  • Multiple Myeloma
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*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
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July 2016   (final data collection date for primary outcome measure)

At least 2 living, blood related relatives, affected with a lymphoproliferative disorder.

18 Years and older
Contact: Emily Hallberg 1-800-610-7093
United States
489-04, U01CA118444
Susan Slager, Mayo Clinic
Mayo Clinic
National Cancer Institute (NCI)
Principal Investigator: Susan Slager, Ph.D. Mayo Clinic
Mayo Clinic
September 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP