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Monoamine Transporter Function and Autonomic Regulation During Psychodynamic Psychotherapy

This study has been completed.
Sponsor:
Collaborator:
University of Eastern Finland
Information provided by (Responsible Party):
Taru Grohn, Kuopio University Hospital
ClinicalTrials.gov Identifier:
NCT00594711
First received: January 7, 2008
Last updated: October 28, 2011
Last verified: October 2011
History of Changes

January 7, 2008
October 28, 2011
January 2000
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Complete list of historical versions of study NCT00594711 on ClinicalTrials.gov Archive Site
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Monoamine Transporter Function and Autonomic Regulation During Psychodynamic Psychotherapy
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Outcome of psychodynamic psychotherapy measured by [123I] nor-B-CIT SPET imaging

Background Psychodynamic psychotherapy is a widely practised form of psychotherapy in the treatment of depression. There is evidence that serotonin transporter (SERT) densities are altered in depression. Preliminary observations have suggested that SERT function may recover in connection with dynamic psychotherapy.

The objective was to determine whether SERT densities change in relation to clinical recovery during psychodynamic psychotherapy.

N=26

Method Twenty six drug-naïve currently depressed (moderate/severe) patients with no previous treatment were recruited for the study. The baseline study included a group of 18 healthy controls. The patients were randomised into psychotherapy and waiting-list control groups. For controls, psychotherapy was started after a 6-month waiting period. [123I] nor-B-CIT SPET imaging was performed at baseline and after 12 months of psychotherapy. For the controls, additional imaging was performed after the 6-month waiting period.
Observational
Observational Model: Case Control
Time Perspective: Prospective
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Retention:   Samples With DNA
Description:

DNA, creatine, B-vitamin,BP from blood samples.
Non-Probability Sample

Patiens of clinic
Depression
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  • 1
    Case-group
  • 2
    Control-group
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
26
December 2008
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Inclusion Criteria:

  • depression

Exclusion Criteria:

  • antidepressive medication
Both
18 Years to 55 Years
No
Contact information is only displayed when the study is recruiting subjects
Not Provided
 
NCT00594711
KUH5703410, 118/9/00
Yes
Taru Grohn, Kuopio University Hospital
Kuopio University Hospital
University of Eastern Finland
Principal Investigator: Pirjo Saarinen, Ph.D. Kuopio University Hospital
Study Director: Johannes Lehtonen, Ph.D Kuopio University Hospital
Study Chair: Lehto Soili, MD Kuopio University Hospital
Study Chair: Minna Valkonen-Korhonen, Ph.D Kuopio University
Study Chair: Pasi Ahola, MD Kuopio University
Study Chair: Mikko Joensuu, MD Kuopio University Hospital
Study Chair: Tommi Tolmunen, Ph.D. Kuopio University Hospital
Kuopio University Hospital
October 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP