High-resolution Computed Tomography (HRCT) Evaluation of Airway Distensibility in Lung Transplant Recipients

This study is currently recruiting participants.
Verified July 2013 by The University of Texas, Galveston
Sponsor:
Information provided by (Responsible Party):
The University of Texas, Galveston
ClinicalTrials.gov Identifier:
NCT00584181
First received: December 20, 2007
Last updated: July 15, 2013
Last verified: July 2013

December 20, 2007
July 15, 2013
August 2007
December 2014   (final data collection date for primary outcome measure)
Spirometry changes [ Time Frame: Two hours (before and after inhalation of ipratropium) ] [ Designated as safety issue: No ]
Assessment of changes in spirometry following inhalation of nebulized ipratropium
Not Provided
Complete list of historical versions of study NCT00584181 on ClinicalTrials.gov Archive Site
Lung volumes [ Time Frame: Two hours (before and after inhalation of ipratropium) ] [ Designated as safety issue: No ]
Assessment of changes in total lung capacity, functional reserve capacity and inspiratory capacity following inhalation of nebulized ipratropium
Not Provided
Radiographic changes in airway caliber [ Time Frame: Two hours (before and after inhalation of ipratropium) ] [ Designated as safety issue: No ]
Assessment of changes in airway caliber as determined by high resolution chest CT images following inhalation of nebulized ipratropium
Not Provided
 
High-resolution Computed Tomography (HRCT) Evaluation of Airway Distensibility in Lung Transplant Recipients
High Resolution Computed Tomographic Evaluation of Airway Distensibility in Lung Transplant Recipients: A Pilot Study

Lung and heart-lung recipients at the University of Texas Medical Branch who have participated in the "Assessment of Cough Reflex in Lung Transplant Recipients" study who meet the specific study inclusion/exclusion criteria will have one study visit where they will undergo lung volume measurements, followed by high resolution CT scan of the lungs within 2 hours. After the initial CT scan, patients will be given a standard dose of Atrovent, followed thirty minutes later by repeat lung volume measurements and CT scan.

Not Provided
Observational
Observational Model: Cohort
Time Perspective: Prospective
Not Provided
Not Provided
Non-Probability Sample

All patients who participated in the "Assessment of Cough Reflex in Lung Transplant Recipients" study who meet the specific inclusion/exclusion criteria for this study

Lung Transplant
Not Provided
A
All eligible patients will undergo the same procedures
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
10
December 2015
December 2014   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • lung transplant recipients >18 years of age
  • at least 12 months or greater from time of transplantation

Exclusion Criteria:

  • hemodynamic instability
  • hypoxemia
  • pneumonia
  • moderate or large pleural effusion
  • clinical evidence of acute rejection
Both
18 Years and older
No
Contact: Alexander G Duarte, MD 409-772-2436 aduarte@utmb.edu
United States
 
NCT00584181
07-247
No
The University of Texas, Galveston
The University of Texas, Galveston
Not Provided
Principal Investigator: Alexander G Duarte, MD University of Texas
The University of Texas, Galveston
July 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP