Assessment of Cough Reflex in Lung Transplant Recipients

The recruitment status of this study is unknown because the information has not been verified recently.
Verified February 2012 by The University of Texas, Galveston.
Recruitment status was  Recruiting
Sponsor:
Information provided by (Responsible Party):
The University of Texas, Galveston
ClinicalTrials.gov Identifier:
NCT00584077
First received: December 20, 2007
Last updated: February 21, 2012
Last verified: February 2012

December 20, 2007
February 21, 2012
April 2000
Not Provided
to evaluate presence and strength of the cough reflex in the lower airway specifically at the level of the main carina and airway anastomosis through the application of mechanical and chemical stimuli [ Time Frame: 15-20 minutes ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT00584077 on ClinicalTrials.gov Archive Site
to assess the presence and strength of the cough reflex in the lower airway for up to one year [ Time Frame: 15-20 minutes ] [ Designated as safety issue: No ]
Same as current
Not Provided
Not Provided
 
Assessment of Cough Reflex in Lung Transplant Recipients
Assessment of Cough Reflex in Lung Transplant Recipients

The purpose of this study is to evaluate the presence of cough reflex in the transplanted lung of patients who have had either a single or double lung transplant or heart-lung transplant at University of Texas Medical Branch. At the 1 year post transplant bronchoscopy, the presence of the cough reflex will be assessed by placing 3 to 5 ml of 5% dextrose (sugar water) or mechanical stimulation with standard bronchial biopsy forceps in three separate areas of the transplanted lung(s). The cough reflex will be assessed by recording the surface electrical activity by placing external electrodes to monitor the movement of abdominal muscles during a cough. The data will be recorded and compared with recordings from coughs recorded using the surface electrical activity of a cough generated by non-transplant patients.

Not Provided
Observational
Observational Model: Cohort
Time Perspective: Prospective
Not Provided
Not Provided
Non-Probability Sample

Single or double lung or heart-lung transplant recipients

Lung Transplantion
Not Provided
A
All enrolled patients receive the same procedures
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
36
September 2012
Not Provided

Inclusion Criteria:

  • Lung transplant recipient
  • Hemodynamically stable
  • Capable of undergoing bronchoscopy

Exclusion Criteria:

  • Pneumonia
  • Hypoxemia (PaO2 < 70)
  • Hemodynamic instability
  • Coagulopathy
  • Thrombocytopenia
Both
18 Years and older
No
Contact: Alexander G Duarte, MD 409-772-2436 aduarte@utmb.edu
United States
 
NCT00584077
00-132
No
The University of Texas, Galveston
The University of Texas, Galveston
Not Provided
Principal Investigator: Alexander G Duarte, MD University of Texas
The University of Texas, Galveston
February 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP