Collection of Tumor Tissue, Blood and Spinal Fluid From Patients With Brain or Spine Tumors

This study has been completed.
Sponsor:
Collaborator:
Rockefeller University
Information provided by:
Memorial Sloan-Kettering Cancer Center
ClinicalTrials.gov Identifier:
NCT00580463
First received: December 20, 2007
Last updated: March 18, 2009
Last verified: March 2009

December 20, 2007
March 18, 2009
January 2000
March 2009   (final data collection date for primary outcome measure)
To establish a repository of CNS tumors or metastases to the CNS and related tissues for current or future studies. [ Time Frame: conclusion of the study ] [ Designated as safety issue: No ]
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Complete list of historical versions of study NCT00580463 on ClinicalTrials.gov Archive Site
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Collection of Tumor Tissue, Blood and Spinal Fluid From Patients With Brain or Spine Tumors
Collection of Tumor Tissue, Blood and Spinal Fluid From Patients With Brain or Spine Tumors

The purpose of the study is to collect samples of brain or spine tumors. Memorial Sloan-Kettering Cancer Center would then store them for use by researchers who study brain or spine cancer and try to find better ways of treating it. We will also collect blood and spinal fluid from patients with brain or spine tumors. The blood and spinal fluids are also used for research studies of cancer and its treatment.

The main objective of the protocol is the establishment of a repository of central nervous system (CNS) tumors or metastases to the CNS and related tissues as an invaluable resource for current or future research studies of the etiology, pathogenesis and treatment of human central nervous system tumors. The database will be established through the intra-operative acquisition of brain or spine tumors as well as the collection of blood and spinal fluids from consenting CNS tumor patients.

Observational
Observational Model: Case-Only
Time Perspective: Prospective
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Retention:   Samples With DNA
Description:

Blood Spinal fluid

Non-Probability Sample

The patient population will include adult and pediatric patients diagnosed with a primary or metastatic central nervous system tumor.

Primary or Metastatic Central Nervous System (CNS) Tumor
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
1128
March 2009
March 2009   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • For acquisition of intra-operative brain or spine tumor specimens, blood specimens and spinal fluid specimens, all patients who undergo surgery for resection or biopsy qualify for inclusion in this protocol.
  • If spinal fluid is not accessed as part of the operative procedure, it will not be collected.
  • All patients must be under the care of one or more members of the MSKCC CNS disease management team at the time of tissue acquisition. Patients may have been previously diagnosed and/or treated at another institution.
  • Subjects are eligible regardless of sex, age or race.
  • Parental or guardian consents will be obtained in the case of minors (less than 18 years of age)

Exclusion Criteria:

  • Patients or their guardians, in case of a minor, may choose to be excluded at any time.
  • If a patient, or guardian, decides to withdraw after some or all of the tissues have been collected, such tissues will be destroyed at their request.
  • Patients or their guardians will be counseled at the time of obtaining their consent, of the possibility of withdrawing from the protocol.
Both
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No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00580463
99-125
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Philip Gutin, MD, Memorial Sloan-Kettering Cancer Center
Memorial Sloan-Kettering Cancer Center
Rockefeller University
Principal Investigator: Philip Gutin, MD Memorial Sloan-Kettering Cancer Center
Memorial Sloan-Kettering Cancer Center
March 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP