Identification of Secreted Markers for Tumor Hypoxia in Patients With Head and Neck or Lung Cancers - Tabular View

Tracking Information

First Received Date ^ICMJE

December 4, 2007

Last Updated Date

November 21, 2008

Start Date ^ICMJE

September 1998

Primary Completion Date

Current Primary Outcome Measures ^ICMJE

Original Primary Outcome Measures ^ICMJE

Change History

Complete list of historical versions of study NCT00568490 on ClinicalTrials.gov Archive Site

Current Secondary Outcome Measures ^ICMJE

Original Secondary Outcome Measures ^ICMJE

Descriptive Information

Brief Title ^ICMJE

Identification of Secreted Markers for Tumor Hypoxia in Patients With Head and Neck or Lung Cancers

Official Title ^ICMJE

Identification of Secreted Markers for Tumor Hypoxia in Patients With Head and Neck or Lung Cancers

Brief Summary

To correlate tumor oxygenation as measured by the Eppendorf electrode with the serum level of secreted proteins known to be induced by tumor hypoxia.

Detailed Description

The endpoints of the study are

To validate the prognostic significance of OPN in H&N and lung cancer patients and to monitor its level during active therapy and follow up for cancer surveillance.
To identify a gene and protein signature for hypoxia in H&N and lung cancer patients.

Study Phase

Study Type ^ICMJE

Observational

Study Design ^ICMJE

Prospective

Condition ^ICMJE

Head and Neck Cancer
Lip Neoplasms
Lip Cancer
Lung Cancer

Intervention ^ICMJE

Procedure: Eppendorf electrode measurements
Procedure: Tumor biopsy
Procedure: flabatomy

Study Arms / Comparison Groups

Publications *

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status ^ICMJE

Recruiting

Enrollment ^ICMJE

600

Completion Date

Primary Completion Date

Eligibility Criteria ^ICMJE

Inclusion Criteria:Newly diagnosed patients with head and neck cancer who has tumor accessible to tumor oxygenation measurement with a microelectrode.

Gender

Both

Ages

18 Years and older

Accepts Healthy Volunteers

Contacts ^ICMJE

Location Countries ^ICMJE

United States

Administrative Information

NCT ID ^ICMJE

NCT00568490

Responsible Party

Study ID Numbers ^ICMJE

SU-11052007-801, 15310; CA67166, 73995, ENT0016, NCT00568490

Study Sponsor ^ICMJE

Stanford University

Collaborators ^ICMJE

National Institutes of Health (NIH)

Investigators ^ICMJE

Principal Investigator:

Quynh-Thu Le

Stanford University

Information Provided By

Stanford University

Verification Date

November 2008

^ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP