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Identification of Secreted Markers for Tumor Hypoxia in Patients With Head and Neck or Lung Cancers

This study is currently recruiting participants.
Study NCT00568490.   Last updated on June 10, 2008.   Information provided by Stanford University

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Descriptive Information Fields
Brief Title  Identification of Secreted Markers for Tumor Hypoxia in Patients With Head and Neck or Lung Cancers
Official Title  Identification of Secreted Markers for Tumor Hypoxia in Patients With Head and Neck or Lung Cancers
Brief Summary

To correlate tumor oxygenation as measured by the Eppendorf electrode with the serum level of secreted proteins known to be induced by tumor hypoxia.

Detailed Description

The endpoints of the study are

  1. To validate the prognostic significance of OPN in H&N and lung cancer patients and to monitor its level during active therapy and follow up for cancer surveillance.
  2. To identify a gene and protein signature for hypoxia in H&N and lung cancer patients.
Study Phase
Study Type  Observational
Study Design  Prospective
Primary Outcome Measure 
Secondary Outcome Measure 
Condition  Head and Neck Cancer
Lip Neoplasms
Lip Cancer
Lung Cancer
Intervention  Procedure: Eppendorf electrode measurements
Procedure: Tumor biopsy
Procedure: flabatomy
MEDLINE PMIDs
Links
Recruitment Information Fields
Recruitment Status  Recruiting
Enrollment  600
Start Date  September 1998
Completion Date
Eligibility Criteria 

Inclusion Criteria:Newly diagnosed patients with head and neck cancer who has tumor accessible to tumor oxygenation measurement with a microelectrode.

Gender Both
Ages 18 Years and older
Accepts Healthy Volunteers No
Contacts ††
Location Countries  United States
Administrative Information Fields
NCT ID  NCT00568490
Organization ID SU-11052007-801
Secondary IDs †† 15310; CA67166, 73995, ENT0016, NCT00185822
Study Sponsor  Stanford University
Collaborators †† National Institutes of Health (NIH)
Investigators 
Principal Investigator:     Quynh-Thu Le     Stanford University    
Information Provided By Stanford University
Verification Date June 2008
First Received Date  December 4, 2007
Last Updated Date June 10, 2008

 †    Required WHO trial registration data element.
††   WHO trial registration data element that is required only if it exists.




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