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| Descriptive Information Fields | |||||||||
| Brief Title † | Biomarkers in the Diagnosis and Assessment of PAH | ||||||||
| Official Title † | Biomarkers in the Diagnosis and Assessment of PAH | ||||||||
| Brief Summary | We Hypothesis that baseline plasma BNP and MIF levels are surrogate markers of clinical severity of PAH and that changes in plasma BNP and MIF levels pre and post exercise. |
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| Detailed Description | As above |
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| Study Phase | |||||||||
| Study Type † | Interventional | ||||||||
| Study Design † | Diagnostic, Open Label, Single Group Assignment | ||||||||
| Primary Outcome Measure † | Assess the correlation of plasma/arterial BNP and MIF levels pre/post with the 6 Minute walk test distance and echocardiographic parameters as surrogate markers of severity of PAH. [ Time Frame: 2 year ] [ Designated as safety issue: No ] | ||||||||
| Secondary Outcome Measure † | To determine if changes in plasma/arterial MIF levels pre/post 6MW test are due to MIF released from the lungs [ Time Frame: 2 year ] [ Designated as safety issue: No ] | ||||||||
| Condition † | Pulmonary Arterial Hypertension | ||||||||
| Intervention † | Other: Blood draw | ||||||||
| MEDLINE PMIDs | |||||||||
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| Recruitment Information Fields | |||||||||
| Recruitment Status † | Recruiting | ||||||||
| Enrollment † | 75 | ||||||||
| Start Date † | May 2007 | ||||||||
| Completion Date | May 2008 | ||||||||
| Eligibility Criteria † | Inclusion Criteria:
Exclusion Criteria:
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| Gender | Both | ||||||||
| Ages | 18 Years to 65 Years | ||||||||
| Accepts Healthy Volunteers | No | ||||||||
| Contacts †† |
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| Location Countries † | United States | ||||||||
| Administrative Information Fields | |||||||||
| NCT ID † | NCT00566423 | ||||||||
| Organization ID | 07-030 | ||||||||
| Secondary IDs †† | NS-LIJHS IRB # 07-030 | ||||||||
| Study Sponsor † | North Shore Long Island Jewish Health System | ||||||||
| Collaborators †† | |||||||||
| Investigators † |
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| Information Provided By | North Shore Long Island Jewish Health System | ||||||||
| Verification Date | February 2008 | ||||||||
| First Received Date † | November 29, 2007 | ||||||||
| Last Updated Date | February 5, 2008 | ||||||||
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