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| Descriptive Information Fields | |||||||||
| Brief Title † | Monitoring Neural Tissues Properties by Modulated Imaging (MI) | ||||||||
| Official Title † | Monitoring Neural Tissues Properties by Modulated Imaging (MI) | ||||||||
| Brief Summary | We have developed a safe, non-contact, intra-operative guidance system to optimize tumor resection in neurosurgery. The Modulated Imaging (MI) is non-contact optical imaging technology developed at the Beckman Laser Institute, UCI. Compared to other imaging approaches, MI has the unique capability of performing both diffuse optical tomography and rapid, wide-field quantitative mapping of tissue optical properties within a single measurement platform. Preliminary in vivo studies have shown that brain tumors, infiltrating tumor margins and normal brain may have intrinsically different optical properties. |
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| Detailed Description | While compatible with time-modulation methods, MI alternatively uses spatially-modulated illumination for imaging of tissue constituents. The MI system consists of
Lastly, tissue fluorescence measurements can be performed by placing a combination of source-blocking and bandpass emission filters in front of the camera. The diffusely reflected amplitude of the modulated wave carries both optical property (absorption, fluorescence, scattering) and depth information. Specifically, the sampling depth of the spatially-modulated wave is a function of the frequency of illumination and the tissue optical properties. During neurosurgery when nervous tissue is exposed by the attending neurosurgeon, intraoperative pictures will be taken using the modulated imager (MI) by the investigators. The imaging procedure may delay completion of the surgical case by an estimated 10 to 20 minutes. This is minimal prolongation considering most brain tumor resections take several hours. The images acquired will be processed after the surgical procedure and will not be available to the surgeon during the operative procedure. |
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| Study Phase | |||||||||
| Study Type † | Observational | ||||||||
| Study Design † | Case-Only, Cross-Sectional | ||||||||
| Primary Outcome Measure † | |||||||||
| Secondary Outcome Measure † | |||||||||
| Condition † | Brain Tumor | ||||||||
| Intervention † | |||||||||
| MEDLINE PMIDs | |||||||||
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| Recruitment Information Fields | |||||||||
| Recruitment Status † | Enrolling by invitation | ||||||||
| Enrollment † | 70 | ||||||||
| Start Date † | January 2008 | ||||||||
| Completion Date | July 2012 | ||||||||
| Eligibility Criteria † | Inclusion Criteria:
Exclusion Criteria:
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| Gender | Both | ||||||||
| Ages | |||||||||
| Accepts Healthy Volunteers | No | ||||||||
| Contacts †† | |||||||||
| Location Countries † | United States | ||||||||
| Administrative Information Fields | |||||||||
| NCT ID † | NCT00555711 | ||||||||
| Organization ID | P41-RR01192; NIH-LAMMP | ||||||||
| Secondary IDs †† | |||||||||
| Study Sponsor † | University of California, Irvine | ||||||||
| Collaborators †† | Beckman Laser Institute Medical Clinic Neurosurgery department,University of California,Irvine, Orange. |
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| Investigators † |
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| Information Provided By | University of California, Irvine | ||||||||
| Verification Date | July 2008 | ||||||||
| First Received Date † | November 7, 2007 | ||||||||
| Last Updated Date | July 25, 2008 | ||||||||
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