Relationship Between Microcirculatory Flow Alterations and Tissue Metabolism

This study has been completed.
Sponsor:
Information provided by:
Medical Centre Leeuwarden
ClinicalTrials.gov Identifier:
NCT00547859
First received: October 22, 2007
Last updated: November 25, 2008
Last verified: November 2008

October 22, 2007
November 25, 2008
November 2007
October 2008   (final data collection date for primary outcome measure)
Relation between MFI (by SDF) and capno [ Time Frame: 6 months ] [ Designated as safety issue: No ]
relation between MFI (by SDF) and capno [ Time Frame: 6 months ]
Complete list of historical versions of study NCT00547859 on ClinicalTrials.gov Archive Site
Relevance of changes in flow and metabolism [ Time Frame: 6 months ] [ Designated as safety issue: No ]
relevance of changes in flow and metabolism [ Time Frame: 6 months ]
Not Provided
Not Provided
 
Relationship Between Microcirculatory Flow Alterations and Tissue Metabolism
Correlation Between Microcirculatory Flow and Rectal Anaerobe Cellular CO2 Production in Patients After Cardiac Surgery

The purpose of this study is to correlate microcirculatory flow and rectal anaerobe cellular CO2 production in patients after cardiac surgery. The hypothesis is that such a correlation exists.

Sidestream Darkfield imaging is used to determine rectal microcirculatory flow in patients after postoperative cardiac surgery. At the same time PCO2 gap is established by monitoring rectal CO2 (tonometry) and arterial CO2 After initial enrollment and first analysis we also includes a control group with equal inclusion criteria for sublingual SDF imaging.

Observational
Observational Model: Cohort
Time Perspective: Prospective
Not Provided
Not Provided
Probability Sample

post cardiac surgery patients in the first two hours of ICU treatment

Cardiac Surgery
Not Provided
Not Provided
Boerma EC, Mathura KR, van der Voort PH, Spronk PE, Ince C. Quantifying bedside-derived imaging of microcirculatory abnormalities in septic patients: a prospective validation study. Crit Care. 2005;9(6):R601-6. Epub 2005 Sep 22.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
30
November 2008
October 2008   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • cardiac surgery
  • informed consent
  • age > 18

Exclusion Criteria:

  • pregnancy
  • off pump procedure
  • rectal fecal contamination
Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
Netherlands
 
NCT00547859
TPO 503, ABR 19609
No
EC Boerma, Medical Center Leeuwarden
Medical Centre Leeuwarden
Not Provided
Principal Investigator: E.C. Boerma, MD Medical Centre Leeuwarden
Medical Centre Leeuwarden
November 2008

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP