Correlation Between Intestinal Parasites and Serum Level of Eosinophils and IgE in Individuals With HIV or AIDS

This study has been completed.
Sponsor:
Information provided by:
UPECLIN HC FM Botucatu Unesp
ClinicalTrials.gov Identifier:
NCT00546689
First received: October 18, 2007
Last updated: April 17, 2008
Last verified: October 2007

October 18, 2007
April 17, 2008
March 2007
Not Provided
all [ Time Frame: one year ]
Same as current
Complete list of historical versions of study NCT00546689 on ClinicalTrials.gov Archive Site
all [ Time Frame: one year ]
Same as current
Not Provided
Not Provided
 
Correlation Between Intestinal Parasites and Serum Level of Eosinophils and IgE in Individuals With HIV or AIDS
Phase 1 Correlation Between Intestinal Parasites and Serum Level of Eosinophils and IgE in Individuals With HIV or AIDS

Correlation between intestinal parasites and serum level of eosinophils and IgE in individuals with HIV or aids attended at clinical hospital of the Botucatu Medical School-UNESP

The present study correlates intestinal parasitism and levels of eosonophils and of serum IgEs in patients attended at the C.H. of the School of Medicine - Botucatu/UNESP. Thirty adult patients with AIDS were analyzed in the use of HAART, aged 42 ±11 years, 14 (46.7%) male, excluding those that had used anthelminthics 30 days prior to collection. Socioeconomic questionaires were applied and 3 samples of feces were taken for parasitological exams (TF-test® method) and 5 ml of blood for counting eosinophils (automated hematological counter, Pentra 80, ABX) and IgE doses (equipment BN-100, Dade-Behring). The index of parasites was 10%, with E.nana (3.3%), E.coli (3.3%) and B.hominis (3.3%). Parasitized individuals were from an urban region with complete basic sanitation and good socioeconomic level. Normal eosinphil values were found in all samples and increased IgE values in 1 (33.3%) sample. The index of parasites was low due to good socioeconomic level and disease control. Augmented IgE levels corroborate the literature, which reports an increase characteristic of immune response in the face of parasitic infections in individuals with HIV or AIDS. In conclusion, new studies should be undertaken to evaluate the level of eosinophils associated with cytokines to obtain a better understanding of this correlation.

Observational
Observational Model: Case-Only
Time Perspective: Prospective
Not Provided
Retention:   Samples Without DNA
Description:

Sample of Blood Sample of Feces

Probability Sample

primary care clinic

HIV Infections
Not Provided
1 , 2
those with HIV
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
30
August 2007
Not Provided

Inclusion Criteria:

  • HIV or AIDS
  • age same or superior to 18 years,
  • both sexes
  • assisted by the Hospital of the Clinics of Botucatu Medical School-UNESP

Exclusion Criteria:

  • use of anthelminthic in the period of 30 days antecedents the it dates from collection
  • individuals that don't have all of the necessary evaluations to the objectives of the study
  • individuals that abandon the attendance, or that you/they are to death during the study
Both
18 Years to 60 Years
No
Contact information is only displayed when the study is recruiting subjects
Not Provided
 
NCT00546689
upeclin/HC/FMB-Unesp-02, Botucatu Medical School UNESP
Yes
Not Provided
UPECLIN HC FM Botucatu Unesp
Not Provided
Study Chair: Paulo C Pereira, Phd Botucatu Medical School - UNESP
UPECLIN HC FM Botucatu Unesp
October 2007

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP