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Optical Sensor for Photodynamic Detection of Oral Pathology

This study is enrolling participants by invitation only.
Sponsor:
Collaborators:
Beckman Laser Institute University of California Irvine
Otolaryngology Medical Clinic,University of California, Irvine
Colgate Palmolive
Information provided by (Responsible Party):
Montana Compton, University of California, Irvine
ClinicalTrials.gov Identifier:
NCT00540774
First received: October 4, 2007
Last updated: October 28, 2014
Last verified: October 2014

October 4, 2007
October 28, 2014
April 2003
July 2018   (final data collection date for primary outcome measure)
Optical Sensor for Photodynamic Detection of Oral Pathology [ Time Frame: up to 12 months ] [ Designated as safety issue: No ]
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Complete list of historical versions of study NCT00540774 on ClinicalTrials.gov Archive Site
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Optical Sensor for Photodynamic Detection of Oral Pathology
Optical Sensor for Photodynamic Detection of Oral Pathology

The researcher can identify the changes in the optical properties of oral tissues, and can compare these with conventional semi-quantitative histo-pathological assessment to (1) determine processes involved in oral pathology and (2) develop a non-invasive tool for the detection, diagnosis and screening of oral pathology.

Researchers of the Beckman Laser Institute have developed non-invasive imaging modalities for assessment of oral tissue.

The Imaging modalities include:

  1. Coherence and Doppler Tomography a non-invasive imaging modality serves as an alternative to invasive tissue biopsy as a diagnostic measure. Non-invasive diagnosis, which is easier to implement and more convenient than tissue biopsy, can also reduce procedural complications.
  2. Laser Speckle Imaging can image the microstructure and blood flow of the oral tissue. This system is valuable in the treatment and diagnosis of both benign and malignant diseases in the oral cavity.
  3. Photon Migration Spectroscopy is a non-invasive optical technique that utilizes intensity-modulated, near-infrared light to quantitatively measure optical properties in thick tissues. The PMS measurements can provide quantitative optical property values that reflect changes in tissue perfusion, oxygen consumption, and cell/matrix development.
Observational
Observational Model: Case-Only
Time Perspective: Prospective
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Non-Probability Sample

Study population will be recruited from University of Californis Irvine and Orange Country Dentists.

Mouth Diseases
Device: detection of oral pathology
detection of oral pathology
Oral tissue
detection of oral pathology
Intervention: Device: detection of oral pathology
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Enrolling by invitation
150
July 2018
July 2018   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Male or Female age 18 years and older
  • Have oral lesion or not have oral lesion
  • Have condition of dry mouth
  • Have condition of Gum disease
  • Non-smoker

Exclusion Criteria:

  • Age less than 18 years old
  • Advanced gum disease, diseases of oral tissue
  • Untreated cavities
  • Pregnant or breastfeeding
  • Immune compromised individuals
Both
18 Years to 75 Years
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00540774
NIH/LAMMP-2002-2805
No
Montana Compton, University of California, Irvine
Montana Compton
  • Beckman Laser Institute University of California Irvine
  • Otolaryngology Medical Clinic,University of California, Irvine
  • Colgate Palmolive
Principal Investigator: Petra Wilder-Smith, DDS,PhD Beckman Laser Institute, University of Calfornia Irvine
University of California, Irvine
October 2014

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP