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Evaluating the Relationship Between Tobacco Use, Anxiety Sensitivity, and Panic in Adolescents

This study is currently recruiting participants.
Information provided by National Institute of Mental Health (NIMH)

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Descriptive Information Fields
Brief Title  Evaluating the Relationship Between Tobacco Use, Anxiety Sensitivity, and Panic in Adolescents
Official Title  Anxiety Sensitivity, Tobacco Use, and Panic Among Adolescents
Brief Summary

This study will determine whether there is a relationship between tobacco use and a heightened response to panic-producing events among adolescents.

Detailed Description

Growing up is hard enough, and adolescence can be a particularly stressful time in people's lives as they adjust to the transition from childhood to adulthood. Peer pressure can add to this anxiety, making it more likely for teens to take part in risky behaviors such as smoking cigarettes. Every day, more than 4,000 teens smoke their first cigarette and nearly half of those teens will become regular, daily smokers. Cigarette smoking is associated with a multitude of health risks, including an increased likelihood of experiencing panic attacks, anxiety disorders, and depression. This study will evaluate a group of teens, ranging from those who have never smoked to those who smoke daily, to determine whether there is a relation between adolescent smoking history and their vulnerability to panic-producing situations.

Participants in this study will undergo a brief medical screening, followed by a short interview that will include several questionnaires regarding emotions, experiences, and personal habits. Participants will then attend a series of laboratory assessments for 1 hour. The first assessment will include a 3-minute voluntary hyperventilation procedure in which participants will be directed when to breathe in and when to breathe out, at a faster rate than normal. Participants will then take part in two computerized tasks: one will be a computerized task that involves blowing up a balloon and deciding when to quit before the balloon pops; the other task will involve choosing hypothetical amounts of money now or after a period of delay. During the laboratory assessments, all participants will have electrodes attached to their bodies and sensors around their chests to measure heart rate, palm sweating, and muscle tension. Results from this study will be used to evaluate the association between smoking and increased panic levels under stressful conditions among adolescents.

Study Phase
Study Type  Observational
Study Design  Cohort, Prospective
Primary Outcome Measure  Relationship between cigarette smoking and panic vulnerability [ Time Frame: Measured at completion of laboratory testing analysis ] [ Designated as safety issue: No ]
Secondary Outcome Measure 
Condition  Panic Disorder
Intervention 
MEDLINE PMIDs
Links
Recruitment Information Fields
Recruitment Status  Recruiting
Enrollment  180
Start Date  June 2007
Completion Date April 2009
Eligibility Criteria 

Inclusion Criteria:

  • Adolescents, ranging from those who have never smoked to those who smoke daily

Exclusion Criteria:

  • Current or past diagnosis of a panic disorder
  • Acute or chronic cardiopulmonary or respiratory illness (e.g., asthma or bronchitis)
  • Pregnant
Gender Both
Ages 12 Years to 17 Years
Accepts Healthy Volunteers Yes
Contacts ††
Contact: Ellen W. Leen-Feldner, PhD     479-575-5329     eleenfe@uark.edu    
Location Countries  United States
Administrative Information Fields
NCT ID  NCT00535964
Organization ID R03 MH077692
Secondary IDs †† DAHBR 96-BHB
Study Sponsor  National Institute of Mental Health (NIMH)
Collaborators ††
Investigators 
Principal Investigator:     Ellen W. Leen-Feldner, PhD     University of Arkansas    
Information Provided By National Institute of Mental Health (NIMH)
Verification Date March 2008
First Received Date  September 25, 2007
Last Updated Date March 6, 2008

 †    Required WHO trial registration data element.
††   WHO trial registration data element that is required only if it exists.




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