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Epidemiology of Fluoroquinolone Resistance in Human Commensal Flora in Patients Hospitalised in Medical Wards

This study has been completed.
Sponsor:
Information provided by:
Association Pour le Recherche en Infectiologie et en Médecine Interne
ClinicalTrials.gov Identifier:
NCT00520715
First received: July 11, 2007
Last updated: December 28, 2007
Last verified: December 2007

July 11, 2007
December 28, 2007
June 2007
February 2008   (final data collection date for primary outcome measure)
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Complete list of historical versions of study NCT00520715 on ClinicalTrials.gov Archive Site
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Epidemiology of Fluoroquinolone Resistance in Human Commensal Flora in Patients Hospitalised in Medical Wards
Epidemiology and Risk Factors Study of the Carriage of Fluoroquinolone Resistant Bacteria in the Commensal Flora of Patients Hospitalised in Medical Wards

Emergence of bacterial resistance to antibiotics, which is a major public health issue, appears to involve predominantly commensal flora. No data exists concerning risk factors for the carriage of fluoroquinolone resistant bacteria in the flora of hospitalised patients. We will conduct a prospective open study including all unselected patients hospitalised in medical wards of one hospital. Nasal, pharyngeal and rectal swabs will be performed upon admission as well as a review of potential risk factors, after patient's information and acceptance. Resistance testing aiming 3 pathogens (Staphylococcus, Streptococcus and E. coli) will be performed on all specimens, and a case control study will compare risk factors from the resistant and non-resistant groups, for each pathogen. A thousand patients should be included in a year's time. This work could help understand risk factors involved in the carriage of fluoroquinolone resistant pathogens, potentially responsible for invasive infections and inter-patient transmission of resistance. Limiting bacterial resistance and transmission is a goal that can be successfully undertaken only if resistance mechanisms, but also risk factors of acquiring resistant bacteria are better understood.

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Observational
Time Perspective: Prospective
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Carriage of Fluoroquinolone Resistant Bacteria in Commensal Flora.
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de Lastours V, Chau F, Tubach F, Pasquet B, Ruppé E, Fantin B. Independent behavior of commensal flora for carriage of fluoroquinolone-resistant bacteria in patients at admission. Antimicrob Agents Chemother. 2010 Dec;54(12):5193-200. Epub 2010 Sep 27.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
640
December 2007
February 2008   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • all adult patients admitted to the internal medicine, oncology, cardiology and geriatric unit of Beaujon Hospital, Clichy, France.
  • patient agreement

Exclusion Criteria:

  • Age < 18
  • patient refusal or incapable
Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
France
 
NCT00520715
FQ/EPI
No
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Association Pour le Recherche en Infectiologie et en Médecine Interne
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Principal Investigator: Victoire de Lastours, MD
Association Pour le Recherche en Infectiologie et en Médecine Interne
December 2007

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP