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Clinicopathological and Molecular Correlation of Acrochordon in Relation to Human Papillomavirus Infection

The recruitment status of this study is unknown because the information has not been verified recently.
Verified February 2007 by National Taiwan University Hospital.
Recruitment status was  Recruiting
Sponsor:
Collaborators:
National Science Council, Taiwan
National Health Research Institutes, Taiwan
Information provided by:
National Taiwan University Hospital
ClinicalTrials.gov Identifier:
NCT00520078
First received: August 21, 2007
Last updated: NA
Last verified: February 2007
History: No changes posted

August 21, 2007
August 21, 2007
August 2007
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No Changes Posted
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Clinicopathological and Molecular Correlation of Acrochordon in Relation to Human Papillomavirus Infection
Clinicopathological and Molecular Correlation of Acrochordon in Relation to Human Papillomavirus Infection

Acrochordon, or soft fibroma, is a common benign skin tumor which is generally regarded as a sign of cutaneous aging or as a reaction to friction since it occurs in the intertriginous areas. Recent studies have shown the presence of human papillomaviruses, especially the mucosal types, on some of the intertriginous lesions. This study is to analyze the different clinical presentations of acrochordon and correlate them with pathologic and molecular human papillomavirus findings. Further goal is to improve the ability to differentiate acrochordon and its possible prevention and treatment. Also, it may have an implication on the transmission and prevention of cervical carcinoma.

Acrochordon, also called soft fibroma, skin tag or fibroepithelial polyp, is a common cutaneous disorder characterized by a polypoid growth composed of fibroblasts in a loose collagenous stroma, sometimes with proliferation of blood vessels. They appear as soft, skin-colored or light brownish skin tumors. Three types of lesions may occur, (1) multiple small, furrowed papules, especially on the neck and in the axillae, (2) single or multiple filiform smooth growths in various locations, and (3) solitary bag-like pedunculated growth, seen most commonly on the lower trunk. Most regard them as a sign of cutaneous aging.

The presence of human papillomaviruses (HPVs), especially the mucosal types, has been demonstrated in acrochordon. Our previous experience on HPV typing of skin tags also confirms this finding. Though HPV is a ubiquitous virus, the presence of mucosal type HPV in non-mucosal sites is exceptional. This investigation is trying to correlate the clinicopathological and HPV molecular typing of acrochordons. A better understanding of acrochordon and its relation to HPV infection may improve the ability to prevent and treat.

Observational
Primary Purpose: Screening
Time Perspective: Cross-Sectional
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  • Acrochordon
  • Skin Tag
  • Soft Fibroma
  • Human Papillomavirus
  • HPV
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
100
August 2008
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Inclusion Criteria:

  • Adult patients with multiple acrochordon on non-anogenital sites who ask to remove the lesions and have signed consent to surgery will be asked to participate in the study

Exclusion Criteria:

  • No special exclusion criteria
Both
20 Years and older
No
Contact: Tsen-Fang Tsai, MD +886-2-23123456 ext 5734 tftsai@yahoo.com
Taiwan
 
NCT00520078
200701034R
Yes
Not Provided
National Taiwan University Hospital
  • National Science Council, Taiwan
  • National Health Research Institutes, Taiwan
Principal Investigator: Tsen-Fang Tsai, MD National Taiwan University Hospital
National Taiwan University Hospital
February 2007

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP