Comparison of Pain Therapeutic Effects After Benign Mastectomy (COPTEAM)

• VAS rating of sedation [ Time Frame: 0h to 24h after the end of the operation ] [ Designated as safety issue: Yes ]
• Overall VAS rating of satisfaction with analgesia [ Time Frame: 24 h after operation ] [ Designated as safety issue: Yes ]
• Incidence of side effects [ Time Frame: From the initiation of analgesia (0 h) to the end of the study (24 h postoperative) ] [ Designated as safety issue: Yes ]

With the incremental trend of benign breast tumor, the surgical process of mastectomy was proceeded too much every day, especially in the Maternal Health Care Hospital, but whether the investigators can find another way to relieve the postoperative pain after such an operation is still unknown. The investigators hypothesized that the pain from the relatively small surgery may not be significant compared to different treatments, even if no drug was delivered to them. The investigators are enrolling patients who underwent mastectomy from benign breast tumor, and are observing the analgesic effects of different drugs.

• Pain, Postoperative
• Mastectomy

• Drug: Saline
  Saline 5 ml administrated intravenously
  Other Name: Physiological solution
• Drug: Opioid
  Butorphanol tartrate 1 mg i.v.
  Other Name: NuoYang
• Drug: Opioid
  Butorphanol Tartrate 2 mg i.v.
  Other Name: NuoYang
• Drug: NSAID
  Flurbiprofen Axetil 50 mg i.v.
  Other Name: CaiFen
• Drug: NSAID
  Flurbiprofen Axetil 100 mg i.v.
  Other Name: CaiFen
• Drug: Opioid
  Tramadol Hydrochloride 10 mg i.v.
  Other Name: Trama
• Drug: Opioid
  Tramadol Hydrochloride 20 mg i.v.
  Other Name: Trama

• Placebo Comparator: I
  No drug was delivered.
  Intervention: Drug: Saline
• Active Comparator: II
  Butorphanol tartrate 1mg was given intravenously.
  Intervention: Drug: Opioid
• Active Comparator: III
  Butorphanol tartrate 2 mg was given intravenously.
  Intervention: Drug: Opioid
• Active Comparator: IV
  Flurbiprofen Axetil 50 mg was given intravenously.
  Intervention: Drug: NSAID
• Active Comparator: V
  Flurbiprofen Axetil 100 mg was given intravenously.
  Intervention: Drug: NSAID
• Active Comparator: VI
  Tramadol Hydrochloride 10 mg was given intravenously.
  Intervention: Drug: Opioid
• Active Comparator: VII
  Tramadol Hydrochloride 20 mg was given intravenously.
  Intervention: Drug: Opioid

Inclusion Criteria:

• Chinese
• No cardiac and pulmonary diseases
• ASA I-II
• No alcohol drinking.

Exclusion Criteria:

• <19yrs, and >65yrs
• History of central active drugs administration
• Drug abuse
• Hypertension
• Diabetes
• Any other chronic diseases.