Visual Impairment, Oscillopsia and Multiple Sclerosis

This study has been terminated.
Sponsor:
Information provided by:
Hospices Civils de Lyon
ClinicalTrials.gov Identifier:
NCT00498199
First received: July 6, 2007
Last updated: September 29, 2010
Last verified: July 2007

July 6, 2007
September 29, 2010
April 2007
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Complete list of historical versions of study NCT00498199 on ClinicalTrials.gov Archive Site
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Visual Impairment, Oscillopsia and Multiple Sclerosis
Visual Impairment, Oscillopsia and Multiple Sclerosis

This study consists of two parts. The first part is a survey to examine vision-specific health-related quality of life in a cohort of patients with multiple sclerosis. We test visual impairment like visual acuity, visual field, colour discrimination, contrast sensitivity, eye movement. The aim of this part is to examine the association between responses to the quality of life scale and objective measures of visual impairment.

The second part is an open controlled study, in which we measure motion detection threshold in MS patients with oscillopsia due to pendular nystagmus and in a group of control subjects. The objective of this part is to determine whether patients with pendular nystagmus develop adaptation to oscillopsia using increased threshold of motion detection. We plan to test the effect of visuo-motor rehabilitation on this threshold in patients with oscillopsia due to pendular nystagmus.

In the first part, 100 patients with multiple sclerosis are included. A vision-specific health-related quality of life scale and neuro-ophthalmological tests are administered. The duration of intervention is about 3 hours by patient and one year to finish this part.

In the second part, we include about 40 of 100 MS patients who present an oscillopsia due to pendular nystagmus and a group of 20 control subjects. The patients and subject will perform a motion detection task and the vision-specific health-related quality of life, the intervention lasting 1 hour. Then the patients will be randomized in one group treated by rehabilitation (one 30 mn session per week during 3 months) and the other one without treatment. A motion detection task and the vision-specific health-related quality of life scale will be performed at the end of the treatment for both groups.

Observational
Observational Model: Cohort
Time Perspective: Prospective
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Probability Sample

Patients with established multiple sclerosis

Multiple Sclerosis
Procedure: visual tests
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Terminated
100
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Inclusion Criteria:

  • Age 18 to 90
  • Patients with established multiple sclerosis
  • Visual impairment recovering from MS
  • Understanding rules task
  • Patient can stay set a long time
  • Patient's agreement
  • Membership to the Social Security
  • No relapsing since three months

Exclusion Criteria:

  • Brain damage
  • Cognitive or behaviour disorder
  • Patients with peripheral vestibular, otologic or ophthalmologic pathology antecedent
  • Not stabilized disease (other one than MS)
  • Patient under guardianship
Both
18 Years to 90 Years
No
Contact information is only displayed when the study is recruiting subjects
France
 
NCT00498199
2006.432
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Hospices Civils de Lyon
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Principal Investigator: Caroline Tilikete, MD Hospices Civils de Lyon
Hospices Civils de Lyon
July 2007

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP