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Does Topical Steroid Treatment Impair the Adrenal Function?

The recruitment status of this study is unknown because the information has not been verified recently.
Verified May 2007 by HaEmek Medical Center, Israel.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
HaEmek Medical Center, Israel
ClinicalTrials.gov Identifier:
NCT00476489
First received: May 21, 2007
Last updated: NA
Last verified: May 2007
History: No changes posted

May 21, 2007
May 21, 2007
May 2007
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No Changes Posted
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Does Topical Steroid Treatment Impair the Adrenal Function?
Low Dose (1mcg) ACTH Stimulation Test for Assessment of the Hypothalamo-Pituitary- Adrenal Axis in Patients Treated With Topical Corticosteroids

The purpose of this study is to determine if topical steroids treatment for different skin diseases suppress the adrenal cortisol production.

Adrenocortical suppression is a potential complication of systemic corticosteroid treatement but also of non systemic therapy like topical therapy.

The normalcy of hypothalamic-pituitary-adrenal axis ( HPA axis) of patients with chronic skin diseases like atopic dermatitis, pemphigus or psoriasis which are treated with topical steroids, will be assessed with the low dose (1mcg) adrenocortocotropin ( ACTH) stimulation test. During this test serum cortisol levels are measured before, 30 and 60 mn after intravenous administration of 1mcg of ACTH (synacthen).The results will be compared with age and sex matched subjects with normal HPA axis as assessed by low dose ACTH stimulation test.

Observational
Observational Model: Case Control
Primary Purpose: Screening
Time Perspective: Cross-Sectional
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  • Hypothalamus-Pituitary-Adrenal Axis Assessement
  • Topical Steroid Therapy in Chronic Skin Diseases
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
50
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Inclusion Criteria:

  • patients receiving daily topical steroids for at least two weeks on 10% or more of body surface.

Exclusion Criteria:

  • patients treated with any form of corticosteroids except topical steroids.
  • patients with known pituitary disease
  • pregnant patients
Both
18 Years to 75 Years
No
Contact: Avraham Ishay, MD 972-4-6495556 ishay_av@clalit.org.il
Contact: Rafael Luboshitzky, MD r_luboshitzky@clalit.org.il
Israel
 
NCT00476489
02307EMC
No
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HaEmek Medical Center, Israel
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Principal Investigator: Avraham Ishay, MD Haemek Medical Center
HaEmek Medical Center, Israel
May 2007

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP