Trial record 1 of 1 for:    NCT00470977
Previous Study | Return to List | Next Study

Treatment of Exudative and Vasogenic Chorioretinal Diseases Including Variants of AMD and Other CNV Related Maculopathy (FVF4140S)

This study has been completed.
Sponsor:
Collaborator:
Genentech
Information provided by (Responsible Party):
Joan, Manhattan Eye, Ear & Throat Hospital
ClinicalTrials.gov Identifier:
NCT00470977
First received: May 4, 2007
Last updated: October 24, 2012
Last verified: October 2012

May 4, 2007
October 24, 2012
May 2007
December 2010   (final data collection date for primary outcome measure)
Safety and tolerability of intravitreal injections of ranibizumab in the treatment of non-AMD variants and other CNV related conditions [ Time Frame: 24 months ] [ Designated as safety issue: Yes ]
Safety and tolerability of intravitreal injections of Ranibizumab in the treatment of non-AMD variants and other CNV related conditions. [ Time Frame: 12 months ]
Complete list of historical versions of study NCT00470977 on ClinicalTrials.gov Archive Site
  • Mean change in central retinal thickness as measured by OCT at month 12 compared to baseline [ Time Frame: 24 months ] [ Designated as safety issue: Yes ]
  • Change in leakage area seen during fluorescein angiography at month 12 as compared with baseline [ Time Frame: 24 months ] [ Designated as safety issue: Yes ]
  • Number of additional injections required following the initial 3 injections [ Time Frame: 24 months ] [ Designated as safety issue: Yes ]
  • Mean change in central retinal thickness as measured by OCT at month 12 compared to baseline [ Time Frame: 12 months ]
  • Change in leakage area seen during fluorescein angiography at month 12 as compared with baseline • Number of additional injections required following the initial 3 injections. [ Time Frame: 12 months ]
  • Number of additional injections required following the initial 3 injections. [ Time Frame: 12 months ]
Not Provided
Not Provided
 
Treatment of Exudative and Vasogenic Chorioretinal Diseases Including Variants of AMD and Other CNV Related Maculopathy
Treatment of Exudative and Vasogenic Chorioretinal Diseases Including Variants of AMD and Other CNV Related Maculopathy With Intravitreal Injection of Lucentis (Ranibizumab Injection)

The purpose of this study is to evaluate the safety and tolerability of intravitreal injections of ranibizumab in the treatment of AMD variants and other choroidal neovascularization (CNV) related conditions (Coats' disease, idiopathic perifoveal telangiectasia, retinal angiomatous proliferation, polypoidal vasculopathy, pseudoxanthoma elasticum, pathological myopia, multi-focal choroiditis, rubeosis iridis) using the incidence and severity of adverse events.

Limited forms of treatment are available that limit the loss of visual acuity. However, the patients may not have any substantial improvement in acuity or function. Therefore there remains a significant unmet need for therapeutic options managing the neovascularization and its consequences.

Lucentis (ranibizumab) injection will be considered as an attempt to control the growth of the abnormal vessels because of evidence suggesting that angiogenic factors, such as vascular endothelial growth factor (VEGF), play a role in the pathogenesis of neovascular non-AMD conditions.

The rationale for the study design is as follows:

A 0.5 mg dose of Lucentis (ranibizumab), a commercially available preparation that is Food and Drug Administration (FDA) approved and labeled for intravitreal injection use for neovascular (wet) age-related macular degeneration will be used.

In AMD variants and other CNV related conditions, vascular endothelial growth factor (VEGF) plays a role in the pathogenesis as in neovascular AMD.

Intravitreal injection of ranibizumab delivers maximal concentration of the antibody fragment to the vitreous cavity with minimal systemic exposure. The dosing schedule, based on considerations of the half-life and the clinical response in patients with neovascularization suggests that a 1-month interval is optimal.

Not Provided
Interventional
Phase 1
Phase 2
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
  • Coats' Disease
  • Idiopathic Retinal Telangiectasia
  • Retinal Angiomatous Proliferation
  • Polypoidal Choroidal Vasculopathy
  • Pseudoxanthoma Elasticum
  • Pathological Myopia
  • Multi-focal Choroiditis
  • Rubeosis Iridis
  • Von Hippel Lindau Disease
  • BEST VITELLIFORM MACULAR DYSTROPHY, MULTIFOCAL (Disorder)
Drug: ranibizumab injection (0.5 mg)
ranibizumab 10mg mg/ml. , 0.3ml/vial, 0.05 ml./injection intravitreally for 3months then prn for the next 21 months.
Other Name: Lucentis
Experimental: (Ranibizumab) Lucentis
(Ranibizumab)Lucentis 0.5%
Intervention: Drug: ranibizumab injection (0.5 mg)
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
18
December 2010
December 2010   (final data collection date for primary outcome measure)

Inclusion Criteria:

Subjects will be eligible if the following criteria are met:

  1. Ability to provide written informed consent and comply with study assessments for the full duration of the study
  2. Age > 18 years
  3. Clinical diagnosis of the following conditions: Coats' disease, idiopathic perifoveal telangiectasia, retinal angiomatous proliferation, polypoidal vasculopathy, pseudoxanthoma elasticum, pathological myopia, multi-focal choroiditis, rubeosis iridis.
  4. Visual acuity of 20/40 to 20/320 in the study eye on the ETDRS visual acuity chart.
  5. Media clarity, pupillary dilation and patient cooperation sufficient to allow OCT testing and retinal photography

Exclusion Criteria:

Subjects who meet any of the following criteria will be excluded from this study:

  1. Any other condition that the investigator believes would pose a significant hazard to the subject if the investigational therapy is initiated
  2. Participation in another simultaneous medical investigation or trial
  3. Patient with significantly compromised visual acuity in the study eye due to concomitant ocular conditions.
  4. Patients who have undergone intraocular surgery within the last 2 months.
  5. Patient participating in any other investigational drug study.
  6. Use of an investigational drug or treatment related or unrelated to the patient's condition within 30 days prior to receipt of study medication (verteporfin, pegaptanib, or other AMD therapy in the study eye)
  7. Patient treated with systemic anti-VEGF or pro-VEGF agents within 3 months before enrollment.
  8. Previous treatment (in either eye) with intravitreal or intravenously administered Avastin (bevacizumab).
  9. Inability to obtain photographs to document CNV (including difficulty with venous access).
  10. Patient with a known adverse reaction to fluorescein dye.
  11. Patient has a history of any medical condition which would preclude scheduled visits or completion of the study.
  12. Patient has had insertion of scleral buckle in the study eye
  13. Patient has received radiation treatment.
  14. Aphakia or absence of the posterior capsule in the study eye. Previous violation of the posterior capsule in the study eye is also excluded unless as a result of yttrium aluminum garnet (YAG) posterior capsulotomy in association with posterior chamber lens implantation.
  15. Pregnancy (positive pregnancy test) or lactation.
  16. Premenopausal women not using adequate contraception. The following are considered effective means of contraception: surgical sterilization or use of oral contraceptives, barrier contraception with either a condom or diaphragm in conjunction with spermicidal gel, an intrauterine device (IUD), or contraceptive hormone implant or patch.
  17. History of glaucoma filtering surgery in the study eye.
  18. Concurrent use of more than two therapies for glaucoma.
  19. Uncontrolled glaucoma in the study eye (defined as intraocular pressure > 30 mm Hg despite treatment with anti-glaucoma medication)
  20. Inability to comply with study or follow-up procedure
Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00470977
Protocol: FVF4140S
No
Joan, Manhattan Eye, Ear & Throat Hospital
Manhattan Eye, Ear & Throat Hospital
Genentech
Principal Investigator: Lawrence A. Yannuzzi, MD LuEsther T. Mertz Retinal Research Center
Manhattan Eye, Ear & Throat Hospital
October 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP