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Trial record 1 of 1 for:    07-N-0139
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Measuring Blood Flow in the Brain

This study has been completed.
Sponsor:
Collaborators:
Information provided by:
National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier:
NCT00466934
First received: April 26, 2007
Last updated: December 30, 2011
Last verified: December 2011

April 26, 2007
December 30, 2011
April 2007
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Complete list of historical versions of study NCT00466934 on ClinicalTrials.gov Archive Site
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Measuring Blood Flow in the Brain
Cross-Validating NIRS With fMRI

This study will test a method of measuring brain blood flow called near infrared spectroscopy (NIRS). It will determine whether NIRS gives the same results as the more commonly used technique, functional magnetic resonance imaging (fMRI).

Healthy normal volunteers between 18 and 60 years of age may be eligible for this study. Participants come to the NIH up to six times for experiments using NIRS and fMRI. They do the following tasks while they are undergoing NIRS or fMRI:

  • looking at a computer monitor while a checkerboard pattern changes
  • wiggling the toes and moving the fingers
  • Reading words on a computer screen and pushing one button if they are plants and another if they are animals.

For NIRS, a frame is placed on the head and held it in place with a metal band. The frame holds sensors that contact the scalp.

For fMRI, the subject lies on a table that can slide in and out of an MRI scanner, a metal cylinder surrounded by a strong magnetic field. fMRI uses a strong magnetic field and radio waves to obtain images of the brain while the subject performs tasks. During the procedure, The subject wears earplugs to muffle the sound of loud knocking noises that occur during scanning.

OBJECTIVE: a) to explore the usefulness of Near Infrared Spectroscopy (NIRS) as a means of mapping brain activity, to see whether the results are similar to those of fMRI and b) to see whether spontaneous brain blood flow changes coincide with changes in behavior.

STUDY POPULATION: 50 healthy volunteers.

DESIGN: The study will look for correlations between NIRS and fMRI signal changes in the same subjects. It will also detect relationships between spontaneous blood flow shifts and shifts and changes in cognitive performance. Finally, NIRS will be combined with a frontal lobe activation task to see if blood flow changes can be detected over the hairless skin of the forehead in a simple, standardized manner that might yield a diagnostic test for frontal injury.

OUTCOME MEASURES: Graded changes in blood flow and oxygen, measured with NIRS and fMRI and variations in response time on a word task.

Observational
Time Perspective: Prospective
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  • Traumatic Brain Injury
  • Healthy
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
31
December 2011
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  • INCLUSION CRITERIA:

Age 18 to 60, inclusive.

EXCLUSION CRITERIA:

  • Pregnancy.
  • History of hypertension.
  • History of any disease of the central nervous system.
  • Current use of sedating medication, including antihistamines.
  • Subjects with any of the following will be excluded from MRI testing: aneurysm clip; implanted neural stimulator; implanted cardiac pacemaker or auto-defibrillator; cochlear implant; ocular foreign body, such as metal shavings; permanent eyeliner; insulin pump; or irremovable body piercing due to the possible dangerous effects of the MRI magnet upon metal objects in the body.
Both
18 Years to 60 Years
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00466934
070139, 07-N-0139
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National Institute of Neurological Disorders and Stroke (NINDS)
  • Department of Defense
  • National Institutes of Health Clinical Center (CC)
  • Center for Neuroscience and Regenerative Medicine (CNRM)
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National Institutes of Health Clinical Center (CC)
December 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP