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A Study of an Encapsulated Cell Technology (ECT) Implant for Patients With Atrophic Macular Degeneration
This study is ongoing, but not recruiting participants.
Study NCT00447954.   Last updated on October 29, 2007.
Information provided by Neurotech Pharmaceuticals
This Tabular View shows the required WHO registration data elements as marked by

A Study of an Encapsulated Cell Technology (ECT) Implant for Patients With Atrophic Macular Degeneration
A Phase II Study of Implants of Encapsulated Human NTC-201 Cells Releasing Ciliary Neurotrophic Factor (CNTF), in Participants With Visual Acuity Impairment Associated With Atrophic Macular Degeneration

The purpose of this study is to look at the safety and effectiveness of CNTF implants on vision in participants with atrophic macular degeneration. This research is being done because there are no effective therapies for people with atrophic macular degeneration. Age-related macular degeneration (AMD) is a condition that affects the macula, the central part of the retina that we use for seeing details. There are two types of AMD, one is the wet type in which new blood vessels grow, also known as choroidal neovascularization (CNV), but the other is the dry type in which the healthy cells die, and that is the target of this study. This is called atrophic macular degeneration. The implant is a small capsule that contains human retinal pigment epithelium cells. These cells have been given the ability to make CNTF and release it through the capsule membrane into the surrounding fluid. In this study, two different CNTF dose levels will be used: a high dose and a low dose, as well as a sham surgery (or placebo) group.

The study will involve about 18 visits over 1½ years for specific tests of the participant's vision and health. These visits may include visual exams, blood draw for laboratory testing, brief medical history and exam, and occasionally a questionnaire (survey), in addition to the visits for the surgical procedures. There will be about 8 centers participating in this study, and up to 48 people enrolled, across the US. Each participant joining the study who has completed initial screening will then be scheduled to have a brief surgical procedure performed on one eye, which may or may not include a very small cell-filled implant. Follow-up visits for repeat assessments will be required regularly to determine if the implant being tested is safe and effective for use to treat AMD.

Phase II
Interventional
Treatment, Randomized, Double-Blind, Dose Comparison, Parallel Assignment, Safety/Efficacy Study
The increase in best-corrected visual acuity (BCVA) using the Electronic Visual Acuity (EVA) technology from baseline to 1 year.
The mean, median, and distribution of change in BCVA over the 18-month follow-up period
change in ERG between baseline and months 12 and 18
change in area of geographic atrophy from baseline to months 12 and 18
change in area of drusen from baseline to months 12 and 18
change in retinal thickness from baseline to months 12 and 18 measured by OCT
and change in quality of life between baseline and months 12 and 18 using NEI-VFQ25.
Macular Degeneration
Drug: NT-501
Related Info This link exits the ClinicalTrials.gov site
 
Active, not recruiting
48
January 2007

Study inclusion / exclusion criteria:

Criteria for patients to qualify for the study include, but are not limited to:

  • Participants must be at least 50 years old
  • Diagnosis of age-related macular degeneration with the presence of geographic atrophy
  • Visual acuity no better than 20/63 and no worse than 20/160
  • History of recent visual acuity loss

The following criteria will exclude patients from the study:

  • Pregnant or lactating females, or females planning to become pregnant during the study or not using an acceptable method of contraception.
  • Age-related macular degeneration with new blood vessel growth
  • Other eye diseases including advanced cataract.
  • Chronic systemic disease requiring continuous treatment with systemic steroids, immunosuppressive medications or insulin.
Both
50 Years and older
No
United States
 
NCT00447954
CNTF 2
Neurotech Pharmaceuticals
Study Director: Weng Tao, M.D., PhD Neurotech Pharmaceuticals
Neurotech Pharmaceuticals
October 2007
March 9, 2007
October 29, 2007

 †    Required WHO trial registration data element.
††   WHO trial registration data element that is required only if it exists.