Metabolic Effects of Acute Cortisol Withdrawal in Adrenal Failure

This study has been completed.
Sponsor:
Information provided by:
University of Aarhus
ClinicalTrials.gov Identifier:
NCT00442390
First received: February 28, 2007
Last updated: NA
Last verified: February 2007
History: No changes posted

February 28, 2007
February 28, 2007
January 2002
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  • insulin sensitivity
  • local protein turnover
  • whole body protein turnover
  • glucose metabolism
  • serum metabolites
  • serum hormone levels
Same as current
No Changes Posted
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Metabolic Effects of Acute Cortisol Withdrawal in Adrenal Failure
Effects of Cortisol on Carbohydrate, Lipid, and Protein Metabolism; Studies of Acute Cortisol Withdrawal in Adrenocortical Failure.

Effects of adrenal steroids is generelly drawn from studies of hypercortisolism. The effects of physiological cortisol substitution and withdrawal is studied and related to the clinical syndrome of adrenal insufficiency.

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Interventional
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Allocation: Randomized
Endpoint Classification: Bio-equivalence Study
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Treatment
Addison Syndrome
Drug: hydrocortisone substitution therapy versus withdrawal
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
10
January 2003
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Inclusion Criteria:

  • Female adrenal failure
  • Age 18-50
  • Written informed content

Exclusion Criteria:

  • Diabetes mellitus
  • Cancer
  • Thromboembolic events
  • Pregnancy and lactation
  • Heart disease
Female
18 Years to 50 Years
No
Contact information is only displayed when the study is recruiting subjects
Not Provided
 
NCT00442390
1998/4375
No
Not Provided
University of Aarhus
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Principal Investigator: Jens Juel Christiansen, PhD University of Aarhus
Study Chair: Claus H Gravholt, MD University of Aarhus
Study Chair: Christian B Djurhuus, PhD University of Aarhus
Study Chair: Per Iversen, PhD University of Aarhus
Study Chair: Jens S Christiansen, Professor University of Aarhus
Study Chair: Ole Schmidt, Professor University of Aarhus
Study Chair: Jørgen Weeke, Professor University of Aarhus
Study Chair: Jens OL Jørgensen, MD University of Aarhus
Study Director: Niels Møller, Professor University of Aarhus
University of Aarhus
February 2007

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP