Epstein-Barr Virus as a Possible Cause for Chronic Fatigue Syndrome

This study has been completed.
Sponsor:
Collaborator:
Ohio State University
Information provided by:
University of Mississippi Medical Center
ClinicalTrials.gov Identifier:
NCT00433355
First received: February 7, 2007
Last updated: March 18, 2009
Last verified: March 2009

February 7, 2007
March 18, 2009
January 2007
August 2008   (final data collection date for primary outcome measure)
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Complete list of historical versions of study NCT00433355 on ClinicalTrials.gov Archive Site
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Epstein-Barr Virus as a Possible Cause for Chronic Fatigue Syndrome
Studies on Epstein-Barr Virus as a Possible Etiological Agent for Chronic Fatigue Syndrome

The purpose of this study is to understand what causes a continuing fatigue for a long time with a number of symptoms occurring at the same time (Chronic Fatigue Syndrome-CFS). Epstein Barr Virus is among the group of viruses that have been associated with a continuing fatigue for a long time with a number of symptoms occurring at the same time, but the cause is still unknown.

Epstein-Barr virus (EBV) is the etiological agent for heterophile positive infectious mononucleosis (IM). It is also an oncogenic herpes virus associated with African Burkitt's lymphoma (BL),nasopharyngeal carcinoma (NPC) and AIDS-associated B-cell lymphomas. EBV is also among a group of viruses that have been associated with chronic fatigue syndrome (CFS), although the etiology of CFS still remains unknown.Findings may lead to hypothesize that EBV enzymes, such as the dUTPase, have the capacity to induce immune dysregulation of the T-cell and NK cell responses and that this immune dysregulation produces immunopathology that results in the symptoms that we call CFS.

Observational
Observational Model: Case Control
Time Perspective: Prospective
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Non-Probability Sample

18 y/o and above with history of CFS matched those without as to age and gender.

Chronic Fatigue Syndrome
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
15
October 2008
August 2008   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Healthy adults for controls.
  • Adults with chronic fatigue syndrome.

Exclusion Criteria:

  • Individuals with significant medical illness in reference to immunosuppressant drug.

Note: We recruit participants in the Mississippi area who could come in our site to provide blood draw.

Both
18 Years and older
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00433355
2006-0265
Yes
Gailen D. Marshall, MD, PhD, The University of Mississippi Medical Center
University of Mississippi Medical Center
Ohio State University
Principal Investigator: Gailen D Marshall, M.D., PhD University of Mississippi Medical Center
University of Mississippi Medical Center
March 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP