Brain Energy Metabolism in Patients With Chronic Liver Disease and Impaired Central Nervous System

This study has been completed.
Sponsor:
Information provided by:
University of Aarhus
ClinicalTrials.gov Identifier:
NCT00424957
First received: January 19, 2007
Last updated: February 4, 2009
Last verified: February 2009

January 19, 2007
February 4, 2009
November 2006
April 2007   (final data collection date for primary outcome measure)
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Complete list of historical versions of study NCT00424957 on ClinicalTrials.gov Archive Site
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Brain Energy Metabolism in Patients With Chronic Liver Disease and Impaired Central Nervous System
Brain Energy Metabolism in Patients With Acute Hepatic Encephalopathy Measured With PET

The purpose of the current study is to look into the pathogenesis of a severe medical condition causing acute episodes on the central nervous system as seen in majority of patients with liver cirrhosis.

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Observational
Observational Model: Case Control
Time Perspective: Cross-Sectional
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Non-Probability Sample

6 patients with liver cirrhosis with an acute episode of hepatic encephalopathy, 6 patients with liver cirrhosis without an acute episode of hepatic encephalopathy, 6 healthy subjects age and sex matched

  • Cirrhosis
  • Hepatic Encephalopathy
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Ott P, Clemmesen O, Larsen FS. Cerebral metabolic disturbances in the brain during acute liver failure: from hyperammonemia to energy failure and proteolysis. Neurochem Int. 2005 Jul;47(1-2):13-8. Review.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
18
October 2008
April 2007   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • 6 patients with liver cirrhosis with an acute episode of hepatic encephalopathy,
  • 6 patients with liver cirrhosis without an acute episode of hepatic encephalopathy,
  • 6 healthy subjects age and sex matched

Exclusion Criteria:

  • Neurological and/or psychiatric condition,
  • Non-treated diabetes,
  • Pregnancy/breast-feeding
Both
45 Years to 65 Years
Yes
Contact information is only displayed when the study is recruiting subjects
Denmark
 
NCT00424957
20060120
Yes
Peter Iversen, PET Center, Aarhus University Hospital
University of Aarhus
Not Provided
Study Chair: Susanne Keiding, MD PET Centre and Medical department V, Aarhus Sygehus, Aarhus University Hospital
University of Aarhus
February 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP