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Prognostic Value of New Cardiac Biomarkers in Elderly Patients Undergoing Cardiac Surgery

This study has been completed.
Sponsor:
Information provided by:
Klinikum Ludwigshafen
ClinicalTrials.gov Identifier:
NCT00416299
First received: December 26, 2006
Last updated: January 29, 2009
Last verified: January 2009

December 26, 2006
January 29, 2009
May 2007
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Complete list of historical versions of study NCT00416299 on ClinicalTrials.gov Archive Site
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Prognostic Value of New Cardiac Biomarkers in Elderly Patients Undergoing Cardiac Surgery
Observational Cohort Study on the Prognostic Value of New Cardiac Biomarkers in Elderly Patients Undergoing Cardiac Surgery

To evaluate the use of new cardiac biomarker for the prediction of in-hospital cardiovascular complications in elderly patients undergoing elective cardiac surgery.

Plasma N-terminal pro-brain natriuretic peptide (NT-proBNP, cardiac troponin T (cTnT), pregnancy-associated plasma protein A (PAPP-A), ischemia-modified albumin (IMA), myeloperoxidase (MPO), metalloproteinase (MMP) soluble CD 40 ligand (sCD40L), and inflammatory cytokine levels will be measured in 100 elderly patients undergoing elective cardiac surgery with cardiopulmonary bypass before induction of anesthesia and 12 h, 24 h, and 48 h after surgery. Optimum discriminators for prediction of postoperative cardiovascular complications wil be determined by the use of receiver operating characteristics (ROC) curves analyses.

Observational
Time Perspective: Prospective
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Cardiac Surgery
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
100
August 2007
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Inclusion Criteria:

  • patients aged 75 years or older undergoing elective cardiac surgery with CPB

Exclusion Criteria:

  • positive cardiac troponin T test within the week before surgery
  • patients undergoing emergent procedures
  • patients with preoperative mechanical cardiac support
  • patients undergoing hemodialysis
Both
75 Years and older
No
Contact information is only displayed when the study is recruiting subjects
Germany
 
NCT00416299
KliLuNTproBNP
No
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Klinikum Ludwigshafen
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Principal Investigator: Stefan W. Suttner, MD Klinikum Ludwigshafen
Klinikum Ludwigshafen
January 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP