Investigation of Genetic Risk of Metabolic Syndrome in Company Employee (NGK Study)

The recruitment status of this study is unknown because the information has not been verified recently.
Verified September 2007 by Nagoya University.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Nagoya University
ClinicalTrials.gov Identifier:
NCT00408824
First received: December 6, 2006
Last updated: September 19, 2007
Last verified: September 2007

December 6, 2006
September 19, 2007
September 2006
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Complete list of historical versions of study NCT00408824 on ClinicalTrials.gov Archive Site
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Investigation of Genetic Risk of Metabolic Syndrome in Company Employee (NGK Study)
Assessment of Genetic Risk of Metabolic Syndrome in Company Employee and Making New Health Guidance Program (NGK Study)

The metabolic syndrome is a highly prevalent disorder, which causes atherosclerotic cardiovascular disease and is closely associated with insulin resistance. The alteration of the secretion of adipocytokines from accumulated visceral adipose tissue in the obese induces insulin resistance. The purpose of this study is to identify gene polymorphisms that confer susceptibility to the metabolic syndrome and to make up a new health guidance program based on genetic risk assessment. About 25% of male employees over 45 years old in a certain company are diagnosed with the metabolic syndrome in medical examination. We, the researchers at Nagoya University, will analyze gene polymorphism and various biomarkers of over 3500 company employees.

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Observational
Observational Model: Case Control
Time Perspective: Longitudinal
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  • Healthy
  • Metabolic Syndrome X
  • Hyperlipidemia
  • Hypertension
  • Diabetes Mellitus
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Tanimura D, Shibata R, Izawa H, Hirashiki A, Asano H, Murase Y, Miyata S, Nakatochi M, Ouchi N, Ichihara S, Yasui K, Yoshida T, Naruse K, Matsubara T, Yokota M. Relation of a common variant of the adiponectin gene to serum adiponectin concentration and metabolic traits in an aged Japanese population. Eur J Hum Genet. 2011 Mar;19(3):262-9. doi: 10.1038/ejhg.2010.201. Epub 2010 Dec 8.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
4000
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Inclusion Criteria:

  • Healthy subjects who work for a certain company
Both
20 Years to 65 Years
Yes
Contact: Kenji Yasui, MD, PhD +81-52-788-6211 kenji@riem.nagoya-u.ac.jp
Japan
 
NCT00408824
RIEM-G-3
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Nagoya University
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Study Chair: Kenji Yasui, MD, PhD Department of Bio-information Analysis, Research Institute of Environmental Medicine, Nagoya University
Nagoya University
September 2007

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP