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Elimination of Albumin-Bound Substances by MARS and Prometheus

This study has been completed.
Sponsor:
Collaborator:
Fresenius Medical Care North America
Information provided by:
Medical University of Graz
ClinicalTrials.gov Identifier:
NCT00407004
First received: December 1, 2006
Last updated: NA
Last verified: November 2006
History: No changes posted

December 1, 2006
December 1, 2006
March 2003
Not Provided
serum levels of albumin-bound substances
Same as current
No Changes Posted
plasma clearance of albumin-bound substances
Same as current
Not Provided
Not Provided
 
Elimination of Albumin-Bound Substances by MARS and Prometheus
Effect of Extracorporeal Liver Support by MARS and Prometheus on Albumin-Bound Substances in Acute-on-Chronic Liver Failure

This trial compares the efficacy of two artificial liver support systems, MARS (Molecular Adsorbents Recirculating System) and Prometheus (FPSA, Fractionated Plasma Separation and Adsorption), in removing albumin-bound substances such as bilirubin, bile acids, and cytokines.

Not Provided
Interventional
Not Provided
Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Treatment
Liver Failure
  • Device: MARS (Molecular Adsorbents Recirculating System)
  • Device: Prometheus (FPSA, Fractionated Plasma Separation and Adsorption)
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
10
April 2004
Not Provided

Inclusion Criteria:

  • consecutive patients with acute-on-chronic liver failure (severe deterioration of chronic liver disease) unresponsive to standard medical treatment for >=48 hours

Exclusion Criteria:

  • arterial hypotension
  • extrahepatic malignancy
Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
Austria
 
NCT00407004
EAT
Not Provided
Not Provided
Medical University of Graz
Fresenius Medical Care North America
Principal Investigator: Rudolf E. Stauber, MD Medical University of Graz
Principal Investigator: Peter Krisper, MD Medical University of Graz
Medical University of Graz
November 2006

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP