A Study of the Safety and Efficacy of CNTO 328 and Bortezomib to Bortezomib Alone in Patients With Relapsed or Refractory Multiple Myeloma

This study is ongoing, but not recruiting participants.
Sponsor:
Information provided by (Responsible Party):
Janssen Research & Development, LLC
ClinicalTrials.gov Identifier:
NCT00401843
First received: November 17, 2006
Last updated: March 31, 2014
Last verified: March 2014

November 17, 2006
March 31, 2014
November 2006
September 2014   (final data collection date for primary outcome measure)
The primary objectives for the study are safety for Part 1 and progression-free survival (PFS) for Part 2 [ Time Frame: progression free survival ] [ Designated as safety issue: No ]
The primary objectives for the study are safety for Part 1 and progression-free survival (PFS) for Part 2
Complete list of historical versions of study NCT00401843 on ClinicalTrials.gov Archive Site
The secondary objectives are to assess other efficacy endpoints (Overall response rate, complete response rate, duration of response, and survival), safety, population pharmacokinetics, pharmacodynamics, and immune response. [ Time Frame: 1 year survival ] [ Designated as safety issue: No ]
The secondary objectives are to assess other efficacy endpoints (Overall response rate, complete response rate, duration of response, and survival), safety, population pharmacokinetics, pharmacodynamics, and immune response.
Not Provided
Not Provided
 
A Study of the Safety and Efficacy of CNTO 328 and Bortezomib to Bortezomib Alone in Patients With Relapsed or Refractory Multiple Myeloma
A Phase 2, Randomized, Double-blind, Placebo-controlled Study Comparing the Combination of CNTO 328 (Anti-IL-6 Monoclonal Antibody) and Velcade� Versus Velcade Alone in Subjects With Relapsed or Refractory Multiple Myeloma

The purpose of Part 1 of the study is to determine the safety of the combination of CNTO 328 and bortezomib. The purpose of Part 2 of the study is to compare the length of progression free survival for those patients given CNTO 328 and bortezomib to those patients given bortezomib alone.

The purpose of this study is to see what effects CNTO 328 has on relapsed or refractory multiple myeloma. The study drug, CNTO 328, is a chimeric (part mouse) antibody (small protein that is important for fighting infection).CNTO 328 blocks a small protein called Interleukin 6 (IL-6). IL-6 is made naturally by your body, and at normal levels is important for inflammatory response. High levels of IL-6 can help cancer cells grow and interfere with chemotherapy drugs killing cancer cells. Cancer-related sickness such as cachexia (weight loss), bone resorption (weakening of your bones), and depression have been linked to high levels of IL-6. CNTO 328 has been shown to slow down tumor growth or shrink tumors when tested in animals. In other clinical trials, over 100 patients have received CNTO 328. There are studies ongoing in participants with kidney cancer, hematologic malignancies (blood cancers such as multiple myeloma), and prostate cancer, to see if CNTO 328 is safe and to see what effects it has on these types of cancer. At this time, it is unknown what effect CNTO 328 has had on the participants' cancer. Bortezomib is a type of drug known as a "proteasome inhibitor." A proteasome is a substance that is found in every cell and it is there to help to break down other substances ('proteins') and has a role in the way cells divide. If the proteasome is inhibited, it cannot perform its function in the cell, and if a cell cannot divide it dies. Over 8000 patients with multiple myeloma and other types of cancer have been treated with bortezomib. Bortezomib has been extensively studied in patients with previously treated multiple myeloma. Based on its established activity in pretreated multiple myeloma, bortezomib is registered in the United States and in Europe for the treatment of multiple myeloma patients who have received at least two prior therapies and have demonstrated disease progression on the last therapy. Bortezomib is currently also being studied in several other cancer types.This study consists of two parts. The purpose of Part 1 is to determine the safety of CNTO 328 and bortezomib when given together as a treatment. The purpose of Part 2 is to compare the safety and effects (good and bad) of the combination of CNTO 328 and bortezomib to the safety and effects of bortezomib alone. About 20 patients will take part in the first part of the study. About 270 patients will take part in the second part of the study at approximately 70 sites in the US, Canada, and Europe. Patients will be in the study for about 12 months, with a follow-up period of around 9 months. The study is divided into four different phases: Screening phase-which lasts up to 4 weeks. During this phase the study doctor will perform tests to see if the patient can participate in the study.Treatment phase-which may last up to 4 cycles of 42 days each during which the patient will be treated with CNTO 328 and bortezomib. Maintenance phase-If the patient benefits from the therapy in the treatment phase, the patient will continue to receive CNTO 328 and bortezomib, but now in cycles of 35 days each. Follow up phase, this includes an end of treatment visit 4 weeks after the patient's last infusion and follow up visits every three months until the patient starts a new anti-cancer treatment. CNTO 328 6mg/kg ( 6 milligrams per kilogram of body weight) will be given intravenously (into the vein) over 2 hours once every 2 weeks. Patients who respond with stable disease or better may receive additional doses. Bortezomib will be given IV (into the vein) at 1.3 mg/m2 over 3-5 seconds twice a week for 2 weeks followed by 1 week of rest.

Interventional
Phase 2
Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Multiple Myeloma
  • Biological: CNTO 328; bortezomib
    6mg/kg IV every 2 weeks for 4 42-day cycles; bortezomib - administered as an IV bolus per product label; dexamethasone - 20 mg daily at disease progression
  • Biological: CNTO 328; placebo; bortezomib
    6mg/kg IV every 2 weeks for 4 42-day cycles; placebo - IV once every two weeks a maximum of 2 35-day cycles; dexamethasone - 20 mg daily at disease progression; bortezomib - administered as an IV bolus per product label
  • Experimental: 002
    CNTO 328; placebo; bortezomib 6mg/kg IV every 2 weeks for 4 42-day cycles; placebo - IV once every two weeks a maximum of 2 35-day cycles; dexamethasone - 20 mg daily at disease progression; bortezomib - administered as an IV bolus per product label
    Intervention: Biological: CNTO 328; placebo; bortezomib
  • Experimental: 001
    CNTO 328; bortezomib 6mg/kg IV every 2 weeks for 4 42-day cycles; bortezomib - administered as an IV bolus per product label; dexamethasone - 20 mg daily at disease progression
    Intervention: Biological: CNTO 328; bortezomib
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
306
September 2014
September 2014   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Measurable secretory disease defined as either serum monoclonal paraprotein, (M-protein) >=1 g/dL or urine monoclonal (light chain) protein (> 200 mg/24 hours)
  • Documented disease progression after at least 1 prior line of therapy but no more than 3 or have had no response to previous treatment (primary refractory disease)
  • ECOG performance status score of <= 2
  • Adequate bone marrow, liver, and renal function

Exclusion Criteria:

  • No prior treatment with bortezomib
  • Not Refractory to high-dose dexamethasone
  • Not >= Grade 2 peripheral neuropathy
  • Have not received an allogeneic bone marrow or allogeneic peripheral blood stem cell transplant
  • No prior or concomitant malignancy (other than multiple myeloma) except adequately treated basal cell or squamous cell carcinoma of the skin, carcinoma in situ of the cervix, or other cancer for which the patient has been disease-free for <= 3 years
Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
United States,   Belgium,   Brazil,   Bulgaria,   Canada,   Czech Republic,   France,   Germany,   Greece,   Hungary,   Netherlands,   Poland,   Portugal,   Romania,   Russian Federation,   Slovakia,   Spain,   United Kingdom
 
NCT00401843
CR012784, C0328T06
Not Provided
Janssen Research & Development, LLC
Janssen Research & Development, LLC
Not Provided
Study Director: Janssen Research & Development, LLC Clinical Trial Janssen Research & Development, LLC
Janssen Research & Development, LLC
March 2014

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP