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Polymorphisms in Inflammatory Cytokines Genes in Subjects With Obstructive Sleep Apnea

The recruitment status of this study is unknown because the information has not been verified recently.
Verified February 2005 by Shaare Zedek Medical Center.
Recruitment status was  Not yet recruiting
Sponsor:
Information provided by:
Shaare Zedek Medical Center
ClinicalTrials.gov Identifier:
NCT00395590
First received: November 2, 2006
Last updated: NA
Last verified: February 2005
History: No changes posted

November 2, 2006
November 2, 2006
November 2006
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No Changes Posted
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Polymorphisms in Inflammatory Cytokines Genes in Subjects With Obstructive Sleep Apnea
A Cross Sectional Study of Patients With Obstructive Sleep Apnea for Polymorphisms in Genes of Inflammatory Cytokines.

Obstructive sleep apnea is a common sleep disorder. It is known to be related with increased body mass, abdominal obesity, insulin resistance and hypertension. It is currently believed to be a feature of the metabolic syndrome. Other features of the metabolic syndrome-such as insulin resistace were found related to inflammation and inflammatory cytokines. Several polymorphisms in the genes that encode interleukin 6,inteleukin 10 and TNF-alpha have significant influence on the amounts of cytokine production. we thus hypothesize that polymorphisms related to increased pruduction are more common in subjects with OSA than in matched controls

Patients attending a sleep apnea clinic for evluation will be recruited. Patients found positive for OSA will be compared to the patients with a negative study for OSA for the prevalence of polymorphisms in genes of inflammatory cytokines and cytokine levels

Observational
Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Cross-Sectional
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Sleep Apnea
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Not yet recruiting
100
November 2007
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Inclusion Criteria:

  • Patients attending the sleep apnea clinic for evaluation

Exclusion Criteria:

  • patients known to have inflammatory conditions
Both
18 Years to 75 Years
No
Contact: michal mates, MD 02-6555111 ext 55650 rheum@szmc.org.il
Contact: Gheona Altarescu
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NCT00395590
5594ctil
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Shaare Zedek Medical Center
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Study Director: mates mates, MD Ben-Gurion University of the Negev
Shaare Zedek Medical Center
February 2005

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP